Regulation of human transketolase-like enzyme

Abstract

Reagents which regulate human transketolase-like enzyme and reagents which bind to human transketolase-like enzyme gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, cancer, anemia, and end-stage renal disease, including sensory periphery neuropathy associated with uremia.

1. A method of screening for candidate modulators of transketolase activity comprising the steps of:
 contacting a protein comprising the amino acid sequence shown in SEQ ID NO:2 with a test compound;  
 assaying for binding between the protein and the test compound; and  
 identifying a test compound that binds to the protein as a candidate modulator of transketolase activity that may be useful for regulating activity of the protein.  
 
     
     
       2. The method of  claim 1  wherein either the test compound or the protein comprises a detectable label. 
     
     
       3. The method of  claim 1  wherein either the test compound or the protein is bound to a solid support.