Registration of nuclear medicine images

Abstract

A method of registering a plurality of functional images includes providing a plurality of functional images, providing a plurality of structural images, each one of which having a known positional relationship to at least one of said plurality of functional images, and finding a first mapping transformation between pairs of functional images based on the first mapping transformation and the positional transformation.

1. A method of registering a plurality of functional images comprising:
 providing a plurality of functional images;  
 providing a plurality of structural images each of which has a known positional relationship to at least one of said plurality of functional images, said known positional relationship being derived from the apparatus and methods used to acquire the respective structural and functional images;  
 finding a first mapping transformation between pairs of structural images comprising matching internal structural features between the images; and  
 determining a second mapping transformation between pairs of functional images based on said first mapping transformation and said positional relationship.  
 
     
     
       2. A method according to  claim 1 , wherein:
 said providing a plurality of functional images comprises acquiring a plurality of functional images based on a first set of acquired data; and  
 said providing a plurality of structural images comprises acquiring a plurality of structural images based on a second set of acquired data different from said first set of acquired data.  
 
     
     
       3. A method according to  claim 1  and including:
 determining reference positions on one of said plurality of structural images; and  
 marking said functional image at points associated with the reference positions using the mapping transformation.  
 
     
     
       4. A method according to  claim 1 , further comprising gating at least one of the structural or functional images to body motions. 
     
     
       5. A method of registering a functional image to a structural diagnostic image comprising:
 providing a functional image;  
 providing a first structural image;  
 providing a second structural image having a known positional relationship to said functional image, said known positional relationship being determined based on the apparatus and methods used to acquire the structural and functional image having the known positional relationship;  
 finding a first mapping transformation between the two structural images comprising matching internal structural features between the images; and  
 determining a second mapping transformation between the functional image and the first structural image based on said first mapping transformation and said positional relationship.  
 
     
     
       6. A method according to  claim 5 , wherein the first functional image is a STET image. 
     
     
       7. A method according to  claim 6 , wherein the second structural image is a SPTCT image. 
     
     
       8. A method according to  claim 6 , wherein the second structural image is a SPECT image. 
     
     
       9. A method according to  claim 7  wherein the first structural image is an X-Ray CT image. 
     
     
       10. A method according to  claim 7  wherein the first structural image is an MRI image. 
     
     
       11. A method according to  claim 8  wherein the first structural image is an Ultrasound image. 
     
     
       12. A method according to  claim 7  wherein said transformation between structural images includes a warping transformation. 
     
     
       13. A method according to  claim 7  wherein said functional and structural images are provided as sets of two dimensional slices and further comprising finding corresponding slices by finding matching slices between sets. 
     
     
       14. A method according to  claim 13  wherein finding matching slices comprises manually matching slices. 
     
     
       15. A method according to  claim 13  wherein finding corresponding slices comprises correlating slices. 
     
     
       16. A method according to  claim 13 , further comprising determining a new set of slices for said first functional image to improve correspondence between slices of said functional and structural images. 
     
     
       17. A method according to  claim 13 , wherein finding a first mapping transformation comprises correlating the two structural images. 
     
     
       18. A method according to  claim 13  wherein the matching is done manually. 
     
     
       19. A method according to  claim 18  wherein the matching is done by correlation. 
     
     
       20. A method according to  claim 13  comprising displaying emphasized features from one registered image on a second registered image. 
     
     
       21. A method according to  claim 13  comprising displaying the difference between two registered images. 
     
     
       22. A method according to  claim 13  comprising displaying a series of images. 
     
     
       23. A method according to  claim 14  comprising displaying overlaid images. 
     
     
       24. A method according to  claim 13  comprising displaying at least one of the images as a three-dimensional image. 
     
     
       25. A method according to  claim 12  wherein said known positional relationship includes a warping transformation. 
     
     
       26. A method according to  claim 5 , wherein:
 said providing a plurality of functional images comprises acquiring a plurality of functional images based on a first set of acquired data; and  
 said providing a plurality of structural images comprises acquiring a plurality of structural images based on a second set of acquired data different from said first sot of acquired data.  
 
     
     
       27. A method according to  claim 5  and including:
 determining reference positions on one of said plurality of structural images; and  
 marking said functional image at points associated with the reference positions using the mapping transformation.  
 
     
     
       28. A method according to  claim 5 , further comprising gating at least one of the functional image, the first structural image, or the second structural image to body motions.