Methods for diagnosis, prediction and treatment of asthma and other inflammatory conditions based on eotaxin coding sequence polymorphism

Abstract

Methods and compositions for diagnosing and treating asthma are provided. The methods involve the discovery of a correlation between an eotaxin gene polymorphism and the ocurrence of asthma.

1. A composition comprising an isolated nucleic acid consisting of the wild type normal eotaxin gene sequence as shown in SEQ ID NO: 1, wherein said nucleic acid includes a guanine to adenine substitution 67 base pairs following the ATG initiation codon of the wild type normal eotaxin gene, whereby counting is initiated at the A in that codon. 
     
     
       2. A composition comprising an isolated oligonucleotide consisting of a nucleotide sequence selected from the group consisted of:
                         AGAAACCACCACCTCTCACG;   (SEQ ID NO: 2)         GAGAATTTGCAGTGAGTCTGT;   (SEQ ID NO: 3)         GGGGCTTACCTGGCCCAAC;   (SEQ ID NO: 4)         GGGGCTTACCTGGCCCAAT;   (SEQ ID NO: 5)         and         TCAAGGAAGGTTCTTAGATCG.   (SEQ ID NO. 6).