Preventives/remedies for proliferative organ diseases chronic arthritic diseases, hypertrophic scar or keloid

Abstract

An agent for prophylaxis or treatment of proliferative organ diseases, chronic arthritic diseases, hypertrophic scars or keloid, comprising an erythropoietin receptor antagonist or a salt thereof.

1. A method for prophylaxis or treatment of proliferative organ diseases, chronic arthritic diseases, hypertrophic scars or keloid, comprising administering an effective amount of an isolated erythropoietin receptor antagonist or a salt thereof to a mammal. 
     
     
       2. The method according to  claim 1 , wherein the isolated erythropoietin receptor antagonist or a salt thereof is an erythropoietin receptor antagonist having a molecular weight of 200 to 5000 or a salt thereof. 
     
     
       3. The method according to  claim 1 , wherein the isolated erythropoietin receptor antagonist or a salt thereof is a peptide consisting of 5 to 30 amino acid residues or a salt thereof. 
     
     
       4. The method according to  claim 1 , wherein the isolated erythropoietin receptor antagonist or a salt thereof is an erythropoietin mimetic peptide selected from the group consisting of EMP6, EMP7, EMP12, EMP22, EMP23, EMP24, EMP25, EMP33 and EMP39 or a salt thereof. 
     
     
       5. The method according to  claim 1 , wherein the isolated erythropoietin receptor antagonist or a salt thereof is EMP9 or a salt thereof. 
     
     
       6. The method according to  claim 1 , wherein the isolated erythropoietin receptor antagonist or a salt thereof is a peptide comprising an amino acid sequence having at least 70% homology to the amino acid sequence of SEQ ID NO: 1 or a salt thereof. 
     
     
       7. The method according to  claim 1 , wherein the isolated erythropoietin receptor antagonist or a salt thereof is an anti-erythropoietin receptor antibody or a salt thereof. 
     
     
       8. The method according to  claim 1 , wherein the proliferative organ disease is cancer or tumor. 
     
     
       9. The method according to  claim 1 , wherein the chronic arthritic disease is rheumatoid arthritis, rheumatoid diseases, chronic arthritis of collagenosis or tendovaginitis. 
     
     
       10. A method for suppressing vascular proliferation comprising administering an effective amount of an isolated erythropoietin receptor antagonist or a salt thereof to a mammal. 
     
     
       11. A method for prophylaxis or treatment of proliferative organ diseases, comprising administering an effective amount of an isolated erythropoietin receptor antagonist or a salt thereof in combination with an effective amount of another anticancer agent or a salt thereof to a mammal.