Methods for preventing and treating diseases and conditions associated with cellular stress

Abstract

This invention relates to methods of preventing and treating diseases and conditions associated with cellular stress. The methods involve administration of an effective amount of a compound of the formula:

1. A method of ameliorating one or more symptoms of an alcohol-induced or alcohol-exacerbated injury to, or condition of, the gastrointestinal tract in a person, said method comprising administering to said person an effective amount of a compound of the formula: 
       
         
           
           
               
               
           
         
       
       wherein the injury or condition is selected from the group consisting of hangover, Crohn's disease, and ulcerative colitis. 
     
     
       2. The method of  claim 1 , wherein said injury or condition is hangover. 
     
     
       3. The method of  claim 1 , wherein administration is carried out either: (i) within two hours prior to drinking an alcoholic beverage; (ii) during the period of drinking alcoholic beverages; (iii) within one hour after drinking the last in a series of alcoholic beverages; (iv) within fourteen hours after drinking the last in a series of alcoholic beverages; or (v) two or more of (i)–(iv). 
     
     
       4. The method of  claim 1 , wherein the total amount of said compound administered over a fourteen-hour period is 10–1,000 mg. 
     
     
       5. The method of  claim 4 , wherein the total amount of said compound administered in said period is 50–500 mg. 
     
     
       6. The method of  claim 5 , wherein the total amount of said compound administered is 100–300 mg. 
     
     
       7. The method of  claim 1 , wherein the injury or condition is Crohn's disease. 
     
     
       8. The method of  claim 1 , wherein the injury or condition is ulcerative colitis.