Human paris-1 antigen and nucleic acids: diagnostic and therapeutic uses

Abstract

The present invention relates to the discovery, identification and characterization of a novel tumor suppressor gene designated PARIS-1. The invention includes nucleotide sequences of the PARIS-1 gene and amino acid sequences of its encoded protein product(s), as well as fragments, derivatives and analogs thereof. The invention also includes the production of PARIS-1 proteins, fragments and derivatives and of antibodies specific for PARIS-1 gene products. The invention further comprises agents and compositions which can modulate the expression of PARIS-1 or PARIS-1 expression products to effect the proliferation of cells which express PARIS-1. One particular embodiment comprises agents and compounds which can slow or ablate the proliferation of prostate tumor cells.

1. An isolated nucleic acid comprising the nucleotide sequence encoding a PARIS-1 protein comprising the amino acid sequence of SEQ ID NO: 4, or the full complement thereof. 
     
     
       2. An isolated nucleic acid consisting of at least 25 contiguous nucleotides of the nucleotide sequence of SEQ ID NO: 3 spanning nucleotides 93–2843, or the full complement thereof. 
     
     
       3. An isolated polypeptide having the amino acid sequence of SEQ ID NO: 4. 
     
     
       4. An isolated nucleic acid comprising the nucleotide sequence of SEQ ID NO: 3, or the full complement thereof. 
     
     
       5. An isolated nucleic acid consisting of at least 25 contiguous nucleotides of the coding sequence of a polynucleotide encoding a PARIS-1 protein comprising the amino acid sequence of SEQ ID NO: 4, or the full complement thereof.