US7115382B1ExpiredUtility

Method for detecting IGFBP-4 protease without detecting IGFBP-4 protease/proMBP Complex

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Assignee: COMO HOLDINGS APSPriority: Mar 15, 1999Filed: Mar 15, 2000Granted: Oct 3, 2006
Est. expiryMar 15, 2019(expired)· nominal 20-yr term from priority
Inventors:Michael Toft OvergaardClaus OxvigCheryl A. Conover
G01N 33/573C07K 16/40
72
PatentIndex Score
15
Cited by
48
References
1
Claims

Abstract

Methods for screening for altered focal proliferation states in non-pregnant patients, which include detecting levels of pregnancy-associated plasma protein-A (PAPP-A) are described. Methods for identifying agents that alter the protease activity of PAPP-A, and pharmaceutical compositions and medical devices that include such agents are also described.

Claims

exact text as granted — not AI-modified
1. A method for detecting PAPP-A- in a biological sample comprising contacting said biological sample with an antibody having specific binding affinity for PAPP-A-, but not PAPP-A-/pro major basic protein complex, to detect PAPP-A- in said biological sample.

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