Nucleic acids encoding TANGO405 and functional fragments and uses thereof

Abstract

The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

1. An isolated nucleic acid molecule selected from the group consisting of:
 a) a nucleic acid molecule comprising a nucleotide sequence which is at least 95% identical to the nucleotide sequence of any of SEQ ID NO:51, SEQ ID NO:52, or the nucleotide sequence of the clone deposited as ATCC Accession number PTA-424, wherein the nucleotide sequence encodes a polypeptide capable of mediating T-cell activation; 
 b) a nucleic acid molecule which encodes a polypeptide which is at least 95% identical to the amino acid sequence of SEQ ID NO:53, wherein the polypeptide is capable of mediating T-cell activation; 
 c) a nucleic acid molecule comprising the nucleotide sequence of any of SEQ ID NO:51, SEQ ID NO:52, or the nucleotide sequence of the clone deposited as ATCC Accession PTA-424, or a full complement thereof; and 
 d) a nucleic acid molecule which encodes a polypeptide comprising the amino acid sequence of SEQ ID NO: 53, or the amino acid sequence encoded by the nucleotide sequence of the clone deposited as ATCC Accession number PTA-424. 
 
     
     
       2. The nucleic acid molecule of  claim 1 , wherein the nucleic acid molecule comprises a nucleotide sequence which is at least 95% identical to the nucleotide sequence of any of SEQ ID NO:51, SEQ ID NO:52, or the nucleotide sequence of the clone deposited as ATCC Accession number PTA-424, wherein the nucleotide sequence encodes a polypeptide capable of mediating T-cell activation. 
     
     
       3. The nucleic acid molecule of  claim 1 , wherein the nucleic acid molecule encodes a polypeptide which is at least 95% identical to the amino acid sequence of SEQ ID NO:53, wherein the polypeptide is capable of mediating T-cell activation. 
     
     
       4. The nucleic acid molecule of  claim 1 , wherein the nucleic acid molecule comprises the nucleotide sequence of any of SEQ ID NO:51, SEQ ID NO:52, or the nucleotide sequence of the clone deposited as ATCC Accession PTA-424, or a full complement thereof. 
     
     
       5. The nucleic acid molecule of  claim 1 , wherein the nucleic acid molecule encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:53, or the amino acid sequence encoded by the nucleotide sequence of the clone deposited as ATCC Accession number PTA-424. 
     
     
       6. The nucleic acid molecule of  claim 1  further comprising nucleic acid sequences encoding a heterologous polypeptide. 
     
     
       7. The nucleic acid molecule of  claim 1 , further comprising vector nucleic acid sequences. 
     
     
       8. An isolated non-human mammalian host cell containing the nucleic acid molecule of  claim 1 . 
     
     
       9. An isolated host cell which contains the nucleic acid molecule of  claim 1 . 
     
     
       10. The host cell of  claim 9  which is a mammalian host cell. 
     
     
       11. A method for producing a polypeptide comprising the amino acid sequence of SEQ ID NO:53 or the amino acid sequence encoded by the nucleotide sequence of the clone deposited as ATCC Accession number PTA-424, the method comprising culturing the host cell of  claim 9  under conditions in which the nucleic acid molecule is expressed.