US7182960B2ExpiredUtilityPatentIndex 41

Pharmaceutical compositions for nasal delivery of oestradiol and norethisterone

Assignee: SERVIER LABPriority: Jul 19, 2001Filed: Jul 18, 2002Granted: Feb 27, 2007

Est. expiryJul 19, 2021(expired)· nominal 20-yr term from priority

Inventors:FONKNECHTEN GILLES WUTHRICH PATRICK TSOUDEROS YANNIS VARIN CLAIRE

A61P 9/00A61P 5/24A61P 5/30A61P 5/34A61P 15/12A61P 19/10B82Y 5/00A61K 47/6951A61K 9/0043A61K 47/40A61K 31/724A61K 31/565A61K 31/569A61K 41/0004

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Abstract

The present invention relates to a pharmaceutical composition for administration by the nasal route of 17-β-oestradiol and norethisterone.

Claims

exact text as granted — not AI-modified

1. An aqueous pharmaceutical composition formulated as a solution for nasal administration, which consists essentially of elements (a)–(d) on a per ml of solution basis:
 (a) 2.5 mg of oestradiol hemihydrate, 
 (b) 3.93 mg of norethisterone, 
 (c) 65 mg of a randomly partially methylated cyclodextrin with an average degree of substitution by methylated groups being approximately 1.7, and 
 (d) 9 mg of sodium chloride, wherein the aqueous pharmaceutical composition has a pH of 6.

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