Method for producing L-lysine using methanol-utilizing bacterium

Abstract

L-Lysine is produced by culturing a methanol-utilizing bacterium which requires L-methionine for its growth and has an ability to produce L-lysine in a medium containing methanol as a main carbon source to produce and accumulate L-lysine in culture and collecting the L-lysine from the culture.

1. A method for producing L-lysine comprising
 a) culturing a methanol-utilizing bacterium which requires L-methionine for its growth and has an ability to produce L-lysine in a medium containing methanol as a main carbon source 
 b) allowing accumulation of L-lysine in a culture, and 
 c) collecting the L-lysine from the culture. 
 
     
     
       2. The method according to  claim 1 , wherein said bacterium is a  Methylophilus  bacterium. 
     
     
       3. The method according to  claim 2 , wherein said  Methylophilus  bacterium is  Methylophilus methylotrophus.    
     
     
       4. The method according to  claim 1 , wherein said  Methylophilus  bacterium is modified so that an enzymatic activity of dihydrodipicolinate synthase and an L-lysine secretion system are enhanced.