Streptogramin derivatives and compositions thereof

Abstract

The present invention discloses and claims pharmaceutical compositions comprising Group A streptogramin derivatives of formula (I) and salts thereof in combination with at least one natural group B streptogramin derivative

1. A pharmaceutical composition comprising at least one group A streptogramin compound of formula (I) or a salt thereof: 
       
         
           
           
               
               
           
         
       
       wherein:
 R 1  is chosen from alkyl groups, alkenyl groups, alkynyl groups, monofluoro substituted alkyl groups, monofluoro substituted alkenyl groups, monofluoro substituted alkynyl groups, polyfluoro substituted alkyl groups, polyfluoro substituted alkenyl groups, polyfluoro substituted alkynyl groups, C 3 –C 6  cycloalkyl groups, a phenylmethyl group, and heterocyclylmethyl groups, wherein said heterocyclyl portion is aromatic, 
 R 2  is chosen from a hydrogen atom, a methyl group, and an ethyl group, 
 the bond 
 
       
         
           
           
               
               
           
         
          is a single bond (27R stereochemistry) or a double bond, 
         unless otherwise stated, said alkyl groups are chosen from straight and branched C 1 –C 6  alkyl groups, 
         unless otherwise stated, said alkenyl groups are chosen from straight and branched C 3 –C 6  alkenyl groups, and 
         unless otherwise stated, said alkynyl groups are chosen from straight and branched C 3 –C 6  alkynyl groups, 
       
       and at least one natural, semi-synthetic or synthetic group B streptogramin compound or salt thereof. 
     
     
       2. The pharmaceutical composition according to  claim 1 , wherein said natural group B streptogramin compound is obtained from a genetically modified strain. 
     
     
       3. The pharmaceutical composition according to  claim 1 , wherein said at least one natural group B streptogramin compound or salt thereof is chosen from pristinamycin IA, pristinamycin IB, pristinamycin IC, pristinamycin ID, pristinamycin IE, pristinamycin IF, pristinamycin IG, virginiamycin S1, virginiamycin S3, virginiamycin S4, vernamycin B, vernamycin C, and etamycin. 
     
     
       4. The pharmaceutical composition according to  claim 1 , wherein said at least one natural group B streptogramin compound or salt thereof is pristinamycin IA. 
     
     
       5. The pharmaceutical composition according to  claim 1 , wherein said at least one natural group B streptogramin compound or salt thereof is chosen from pristinamycin IB. 
     
     
       6. The pharmaceutical composition according to  claim 1 , wherein said at least one natural group B streptogramin compound or salt thereof is chosen from pristinamycin IC. 
     
     
       7. The pharmaceutical composition according to  claim 1 , wherein said at least one natural group B streptogramin compound or salt thereof is chosen from pristinamycin ID. 
     
     
       8. The pharmaceutical composition according to  claim 1 , wherein said at least one natural group B streptogramin compound or salt thereof is chosen from pristinamycin IE. 
     
     
       9. The pharmaceutical composition according to  claim 1 , wherein said at least one natural group B streptogramin compound or salt thereof is chosen from pristinamycin IF. 
     
     
       10. The pharmaceutical composition according to  claim 1 , wherein said at least one natural group B streptogramin compound or salt thereof is chosen from pristinamycin IG. 
     
     
       11. The pharmaceutical composition according to  claim 1 , wherein said at least one natural group B streptogramin compound or salt thereof is chosen from virginiamycin S1. 
     
     
       12. The pharmaceutical composition according to  claim 1 , wherein said at least one natural group B streptogramin compound or salt thereof is chosen from, virginiamycin S3. 
     
     
       13. The pharmaceutical composition according to  claim 1 , wherein said at least one natural group B streptogramin compound or salt thereof is chosen from virginiamycin S4. 
     
     
       14. The pharmaceutical composition according to  claim 1 , wherein said at least one natural group B streptogramin compound or salt thereof is chosen from vernamycin B. 
     
     
       15. The pharmaceutical composition according to  claim 1 , wherein said at least one natural group B streptogramin compound or salt thereof is chosen from vernamycin C. 
     
     
       16. The pharmaceutical composition according to  claim 1 , wherein said at least one natural group B streptogramin compound or salt thereof is chosen from etamycin. 
     
     
       17. The pharmaceutical composition according to  claim 1 , further comprising at least one agent chosen from pharmaceutically acceptable diluents and pharmaceutically acceptable adjuvants. 
     
     
       18. A pharmaceutical composition comprising at least one group A streptogramin compound of formula (I) or a salt thereof: 
       
         
           
           
               
               
           
         
       
       wherein:
 R 1  is chosen from alkyl groups, alkenyl groups, alkynyl groups, monofluoro substituted alkyl groups, monofluoro substituted alkenyl groups, monofluoro substituted alkynyl groups, polyfluoro substituted alkyl groups, polyfluoro substituted alkenyl groups, polyfluoro substituted alkynyl groups, C 3 –C 6  cycloalkyl groups, a phenylmethyl group, and heterocyclylmethyl groups, wherein said heterocyclyl portion is aromatic, 
 R 2  is chosen from a hydrogen atom, a methyl group, and an ethyl group, 
 the bond 
 
       
         
           
           
               
               
           
         
          is a single bond (27R stereochemistry) or a double bond, 
         unless otherwise stated, said alkyl groups are chosen from straight and branched C 1 –C 6  alkyl groups, 
         unless otherwise stated, said alkenyl groups are chosen from straight and branched C 3 –C 6  alkenyl groups, and 
         unless otherwise stated, said alkynyl groups are chosen from straight and branched C 3 –C 6  alkynyl groups, 
       
       and one natural group B streptogramin compound or salt thereof, which is pristinamycin IA, and wherein pristinamycin IA is obtained from a genetically modified strain. 
     
     
       19. The pharmaceutical composition according to  claim 18 , further comprising at least one agent chosen from pharmaceutically acceptable diluents and pharmaceutically acceptable adjuvants.