Nematode PAN and ZP receptor-like sequences

Abstract

Nucleic acid molecules from nematodes encoding PAN and ZP domain containing receptor polypeptides are described. PANZP polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PANZP nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.

1. A purified polypeptide comprising an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:10, wherein the polypeptide comprises six PAN domains and one ZP domain and is a secreted membrane-bound protein. 
     
     
       2. A purified polypeptide comprising the amino acid sequence of SEQ ID NO:10. 
     
     
       3. A purified polypeptide comprising an amino acid sequence that differs from the amino acid sequence of SEQ ID NO: 10 by no more than 20 conservative amino acid substitutions, wherein the polypeptide comprises six PAN domains and one ZP domain and is secreted membrane-bound protein. 
     
     
       4. A purified polypeptide consisting of the amino acid sequence of SEQ ID NO: 10.