US7276585B2ExpiredUtilityA1
Immunoglobulin variants outside the Fc region
Est. expiryMar 24, 2024(expired)· nominal 20-yr term from priority
C07K 2317/92C07K 16/32C07K 2317/24C07K 16/00C07K 2317/567C07K 2317/53C07K 2317/732C07K 16/2893A61P 43/00C07K 2317/56C07K 2317/52
99
PatentIndex Score
197
Cited by
455
References
1
Claims
Abstract
The present invention relates to antibody variants outside the Fc region that alter binding affinity to one or more effector ligands, methods for their generation, and their therapeutic application.
Claims
exact text as granted — not AI-modifiedWe claim:
1. An antibody variant comprising at least one amino acid modification in the light chain, said modification selected from the group consisting of R108Q, R108D, R108I, T109P, T109R, and T109D, wherein said antibody variant has increased affinity for FcγRIIIa as compared to the parent antibody, and wherein the number is according to the EU numbering scheme.Cited by (0)
No later patents cite this yet.
References (0)
No backward citations on record.