Combinations of a vanilloid antagonist and an NSAID for the treatment of pain

Abstract

A method of treating conditions associated with pain and alleviating the symptoms associated therewith which comprises administering to a mammal, including man, a vanilloid VR-1 antagonist or a pharmaceutically acceptable derivative thereof and an NSAID or a pharmaceutically acceptable derivative thereof, wherein said VR-1 antagonist or said NSAID may optionally be administered as a sub-maximal amount.

1. A method of treating pain in a mammal comprising administering to the mammal a VR-1 agonist in conjunction with an NSAID, wherein the VR-1 agonist is 1) N-(2-Bromophenyl)-N′-[((R)-1-(5-trifluoromethyl-2-pyridyl)pyrrolidin-3-yl)]urea or a pharmaceutically acceptable salt thereof; and 2) the NSAID is rofecoxib or a pharmaceutically acceptable salt thereof. 
     
     
       2. The method of  claim 1  wherein the VR-1 agonist and the NSAID are each administered in a sub-maximal amount.