Methods for the preparation, formulation and use of lithium valproate

Abstract

The present invention relates to methods for preparing lithium valproate and administering this compound to a subject in need of treatment with lithium and/or valproate. Pharmaceutical compositions are also provided that are useful therapies for the treatment of neurological, immunological, and viral-mediated disorders in warm-blooded mammals.

1. A method of preparing a pharmaceutical quality lithium valproate composition, comprising adding a lithium alkoxide to valproic acid in a hydrocarbon solution and recovering the lithium valproate. 
     
     
       2. The method of  claim 1 , wherein the hydrocarbon solution is selected from the group consisting of petroleum ether, pentane, hexane, heptane, octane, benzene, toluene, and xylene. 
     
     
       3. The method of  claim 1 , wherein the hydrocarbon solution is a mixture of a hydrocarbon and an alcohol selected from the group consisting of methanol, ethanol, propanol, and 2-propanol.