Composition comprising Melissa leaf extract for anti-angiogenic and matrix metalloproteinase inhibitory activity

Abstract

The present invention relates to a composition comprising Melissa leaf extract that inhibits angiogenesis and matrix metalloproteinase activity. The Melissa leaf extract of the present invention inhibits angiogenesis and activity of matrix metalloproteinase, so that it can be applied to treat or prevent diseases related to angiogenesis and matrix metalloproteinase. The composition of the present invention comprising Melissa leaf extract may also comprise more than one component of the other anti-angiogenic, anti-cancer, anti-inflammatory and anti-aging components. This particular composition comprising Melissa leaf extract can be used for pharmaceutical, dietetic and/or cosmetic purposes.

1. A method of inhibiting angiogenesis and an angiogenesis associated disease, comprising administering an angiogenesis inhibiting effective amount of a composition comprising  Melissa  leaf extract to a subject suffering from said angiogenesis associated disease, wherein the  Melissa  leaf extract is administered in an amount of from about 5 mg to about 2000 mg per day. 
     
     
       2. The method according to  claim 1 , wherein the composition further comprises  Morus alba  extract. 
     
     
       3. The method according to  claim 1 , wherein the angiogenesis associated disease is selected from the group consisting of cancer metastasis, angioma, angiofibroma, diabetic retinopathy, premature infant's retinopathy, neovascular glaucoma, corneal disease induced by angiogenesis, involutional macula, macular degeneration, pterygium, retinal degeneration, retrolental fibroplasias, granular conjunctivitis, telangiectasis, pyogenic granuloma, and seborrheic dermatitis. 
     
     
       4. The method according to  claim 1 , where the amount is from about 10 mg to about 1,000 mg per day.