Inhibitors of the fatty acid oxidation for the prophylaxis and/or the treatment of chronic and/or atopic skin diseases

Abstract

The invention relates to a method of preventing and/or treating a chronic and/or an atopic skin disease by administering an inhibitor of fatty acid oxidation to a patient in a pharmacologically effective amount. Furthermore, the invention relates to the use of at least one inhibitor of fatty acid oxidation for the preparation of a pharmaceutical composition for the prophylaxis and/or treatment of a chronic and/or an atopic skin disease.

1. A method of treating psoriasis in a patient in need thereof by administering 2-(6-(4-chlorophenoxy)hexyl)oxirane-2-carboxylic acid ethyl ester (Etomoxir) to a patient in a pharmacologically effective amount. 
     
     
       2. The method according to  claim 1 , wherein the patient is human. 
     
     
       3. The method according to  claim 1 , wherein the 2-(6-(4-chlorophenoxy)hexyl)oxirane-2-carboxylic acid ethyl ester is administered topically. 
     
     
       4. The method according to  claim 1 , wherein the 2-(6-(4-chlorophenoxy)hexyl)oxirane-2-carboxylic acid ethyl ester is administered together with at least one excipient and/or auxiliary. 
     
     
       5. The method according to  claim 4 , wherein the excipient and/or auxiliary is selected from the group consisting of one or more suitable adjuvant(s), one or more pharmaceutically active and/or acceptable carrier(s), diluent(s), filler(s), binder(s), disintegrant(s), lubricant(s), glident(s), coloring agent(s), flavoring agent(s), opaquing agent(s) and plasticizer(s). 
     
     
       6. The method according to  claim 4 , wherein the 2-(6-(4-chlorophenoxy)hexyl)oxirane-2-carboxylic acid ethyl ester is administered topically and the said at least one excipient and/or auxiliary is hydrophobic and is selected from the group consisting of petroleum jelly, wax, oleyl alcohol, propylene glycol monostearate, propylene glycol monopalmitostearate, isopropyl laureate, isopropyl myristate, isopropyl palmitate, isopropyl stearate, ethyl myristate, propyl myristate, butyl myristate, ethyl oleate, Cetylstearyl alcohol, lanolin alcohol and paraffin oil.