Cyclic onium compounds and glucosidase inhibitors

Abstract

Cyclic onium compounds reresented by the following structural formula (I), glucosidase inhibitors using such compounds, and antidiabetic drugs or food containing such glucosidase inhibitor. wherein A − is an aniom; m is an interger between 1 and 6, n is 0 or 1, X + is S + or N + Q (where Q is H or an alkyl of 1 to 4 carbon atoms).

1. Cyclic onium compounds represented by the following structural formula (I) 
       
         
           
           
               
               
           
         
       
       wherein A −  is an anion; m is an integer between 1 and 6, n is 0, and X +  is S + . 
     
     
       2. Cyclic onium compounds according to  claim 1  Wherein m is 2 or 5. 
     
     
       3. Cyclic onium compounds represented by the following structural formula (II): 
       
         
           
           
               
               
           
         
       
       wherein A −  is an anion. 
     
     
       4. Cyclic onium compounds according to any of  claims 1 ,  2 , or  3  wherein A −  is selected from the group consisting of halogen ions, Lewis acid ions, R 1 —SO 3   −  (wherein R 1  is an alkyl of 1 to 4 carbon atoms or an alkyl halide), and R 2 —OSO 3   −  (wherein R 2  is an alkyl of 1 to 4 carbon atoms). 
     
     
       5. Cyclic onium compounds according to  claim 1  wherein A −  is selected from the group consisting of halogen ions, anions originating from Lewis acid, R 1 —SO 3   −  (wherein R 1   is an alkyl of 1 to 4 carbon atoms or an alkyl halide), or R 2 —OSO 3   −  (wherein R 2  is an alkyl of 1 to 4 carbon atoms). 
     
     
       6. Cyclic onium compounds according to  claim 4  wherein A −  is CH 3 —OSO 3   −  or Cl−. 
     
     
       7. Cyclic onium compounds according to  claim 5  wherein A −  is CH 3 —OSO 3   −  or Cl−. 
     
     
       8. Antidiabetic drugs or food containing a glucosidase inhibitor according to any of  claims 1 ,  2  or  3 . 
     
     
       9. Antidiabetic drugs or food containing the glucosidase inhibitor according to  claim 1 . 
     
     
       10. Antidiabetic drugs or food containing the glucosidase inhibitor according to  claim 4 . 
     
     
       11. Antidiabetic drugs or food containing the glucosidase inhibitor according to  claim 5 . 
     
     
       12. Antidiabetic drugs or food containing the glucosidase inhibitor according to  claim 4 . 
     
     
       13. Antidiabetic drugs or food containing the glucosidase inhibitor according to  claim 7 . 
     
     
       14. The cyclic onium compound of  claim 1  wherein m is an integer between 2 and 5.