Biologically absorbable coatings for implantable devices based on polyesters and methods for fabricating the same

Abstract

Polymers containing polyesters and, optionally, agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable substrate having a coating, and the coating contains a polymer comprising a polymeric product of a reaction comprising a polyol and a polycarboxylic acid.

What is claimed is: 
     
       1. A polymer comprising a structure of a formula: 
       
         
           
           
               
               
           
         
         where R 1  and R 3  are different from each other and each comprises a component selected from a group consisting of substituted, unsubstituted, hetero-, straight-chained, branched, cyclic, saturated and unsaturated aliphatic radicals; 
         R 2  and R 4  each comprises a component independently selected from a group consisting of substituted, unsubstituted, hetero-, straight-chained, branched, cyclic, saturated and unsaturated aliphatic radicals; and substituted, unsubstituted, and hetero- aromatic radicals; 
         the grouping 
       
       
         
           
           
               
               
           
         
          is derived from polyacid HOOC—R 1 —COOH and diol HO—R 2 —OH; 
         the grouping 
       
       
         
           
           
               
               
           
         
          is derived from polyacid HOOC—R 3 —COOH and diol HO—R 4 —OH; 
         polyacid HOOC—R 1 —COOH and polyacid HOOC—R 3 —COOH are each an aliphatic dicarboxylic acid independently selected from the group consisting of malonic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, undecanedioic acid, dodecandioic acid, tridecanedioic acid, tetradecanedioic acid, petadecanedioic acid, hexadecanedioic acid, citric acid, maleic acid and fumaric acid; 
         L 1  is an optional linkage; 
         X is an optional agent; 
         L 2  is an optional linkage connecting X to the polymer; and 
         m and n are integers not equal to 0. 
       
     
     
       2. The polymer of  claim 1 , wherein X comprises a component selected from a group consisting of poly(ethylene glycol), poly(propylene glycol), poly(N-vinyl pyrrolidone), phosphorylcholine, a glycosaminoglycan, carboxymethylcellulose, hyaluronic acid, heparin, hirudin, poly(acrylamide methyl propane sulfonic acid), poly(styrene sulfonate), sulfonated dextran, dermatan sulfate, RGD, collagen, chitin, chitosan, elastin and any derivatives, analogs, homologues, congeners, salts, copolymers and combinations thereof. 
     
     
       3. The polymer of  claim 1 , wherein X comprises poly(ethylene glycol), poly(N-vinyl pyrrolidone), phosphorylcholine, hyaluronic acid, heparin, hirudin, or any derivatives, analogs, homologues, congeners, salts, copolymers or combinations thereof. 
     
     
       4. The polymer of  claim 1 , wherein X comprises a component selected from a group consisting of a free radical scavenger, a nitric oxide donor, rapamycin, everolimus, tacrolimus, paclitaxel, docetaxel, estradiol, clobetasol, idoxifen, tazarotene and any prodrugs, metabolites, analogs, homologues, congeners, and any derivatives, salts and combinations thereof. 
     
     
       5. The polymer of  claim 4 , wherein the free radical scavenger comprises a component selected from a group consisting of 2,2′,6,6′-tetramethyl-1-piperidinyloxy free radical; 4-amino-2,2′,6,6′-tetramethyl-1-piperidinyloxy free radical; 4-hydroxy-2,2′,6,6′-tetramethyl-piperidene-1-oxy free radical; 2,2′,3,4,5,5′-hexamethyl-3-imidazolinium-1-yloxy methyl sulfate free radical; 16-doxyl-stearic acid free radical; superoxide dismutase mimic; and any analogs, homologues, congeners, derivatives, salts and combinations thereof. 
     
     
       6. The polymer of  claim 4 , wherein the free radical scavenger comprises TEMPO or any analogs, homologues, congeners, derivatives, salts or combinations thereof. 
     
     
       7. The polymer of  claim 4 , wherein the nitric oxide donor comprises a component selected from the group consisting of S-nitrosothiols, nitrites, N-oxo-N-nitrosamines, substrates of nitric oxide synthase, diazenium diolates and any analogs, homologues, congeners, derivatives, salts and combinations thereof. 
     
     
       8. The polymer of  claim 1 , wherein L 1  and L 2  each comprises a component independently selected from a group consisting of amides, esters, anhydrides, orthoesters, all-aromatic carbonates, ureas, urethanes, semicarbazones, imines, oximes, ketals, acetals, disulfides, or a combination thereof.