Use of indazole derivatives for the treatment of neuropathic pain

Abstract

Use of a compound of formula (I), wherein X is CH or N, and when X is CH, R is H, OH, a linear or branched alkyl chain having from 1 to 3 carbon atoms, a linear or branched alkoxy chain having from 1 to 3 carbon atoms, or a halogen atom, and when X is N, R is H, or an acid addition salt thereof with a pharmaceutically acceptable organic or inorganic acid, to prepare a pharmaceutical composition active in the treatment of neuropathic pain.

1. A method for treating neuropathic pain comprising administering to a human subject having neuropathic pain, 0.001 to 100 mg/kg/day of to a subject having neuropathic pain the compound of formula I: 
       
         
           
           
               
               
           
         
         wherein X is CH or N, and 
         when X is CH, R is H, OH, a linear or branched alkyl chain having from 1 to 3 carbon atoms, a linear or branched alkoxy chain having from 1 to 3 carbon atoms, or a halogen atom, and 
         when X is N, R is H; 
         or an acid addition salt thereof with a pharmaceutically acceptable organic or inorganic acid. 
       
     
     
       2. The method of  claim 1 , wherein X is N and R is H in the compound of formula (I). 
     
     
       3. The method of  claim 1 , wherein X is CH and R is H in the compound of formula (I). 
     
     
       4. The method of  claim 1 , wherein X is CH and R is OH in the compound of formula (I). 
     
     
       5. The method of  claim 1 , wherein X is CH and R is halogen in the compound of formula (I). 
     
     
       6. The method of  claim 1 , wherein X is CH and R is a linear or branched alkyl chain having from 1 to 3 carbon atoms in the compound of formula (I). 
     
     
       7. The method of  claim 1 , wherein X is CH and R is a linear or branched alkoxy chain having from 1 to 3 carbon atoms in the compound of formula (I). 
     
     
       8. The method of  claim 1 , wherein the human has neuropathic pain resulting from diabetes. 
     
     
       9. The method of  claim 1 , wherein the human has neuropathic pain resulting from immunodeficiency. 
     
     
       10. The method of  claim 1 , wherein the human has neuropathic pain resulting from trauma. 
     
     
       11. The method of  claim 1 , wherein the human has neuropathic pain resulting from ischaemia. 
     
     
       12. The method of  claim 1 , wherein the human has neuropathic pain resulting from multiple sclerosis. 
     
     
       13. The method of  claim 1 , wherein the human has neuropathic pain resulting from sciatic neuralgia. 
     
     
       14. The method of  claim 1 , wherein the human has neuropathic pain resulting from trigeminal neuralgia. 
     
     
       15. The method of  claim 1 , wherein the human has neuropathic pain resulting from a post-herpetic syndrome.