Human cytokine receptor

Abstract

Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.”

1. A heterodimeric receptor complex comprising an isolated soluble cytokine receptor polypeptide,
 wherein the isolated soluble cytokine receptor polypeptide comprises an amino acid sequence having at least 95% sequence identity to amino acid residues 21 to 231, 22 to 231, or 22 to 210 of SEQ ID NO:2, and 
 wherein the isolated polypeptide binds IL-TIF (SEQ ID NO:15) or antagonizes IL-TIF (SEQ ID NO:15) activity, and 
 further comprising a soluble zcytor11 (SEQ ID NO:34) receptor polypeptide. 
 
     
     
       2. A heterodimeric receptor complex comprising an isolated soluble cytokine receptor polypeptide comprising amino acid residues 22 to 231 or 22 to 210 of SEQ ID NO:2, and a soluble zcytor11 (SEQ ID NO:34) receptor polypeptide. 
     
     
       3. An isolated heterodimeric soluble receptor complex comprising a first soluble cytokine receptor polypeptide and a second soluble cytokine receptor polypeptide, wherein the first soluble cytokine receptor polypeptide comprises amino acid residues 22 to 231 or 22 to 210 of SEQ ID NO:2, and wherein the second soluble cytokine receptor polypeptide comprises a soluble zcytor11 (SEQ ID NO:34) receptor polypeptide.