US7749518B2ExpiredUtilityPatentIndex 90

Polypeptides from non-typeable Haemophilus influenzae

Assignee: NOVARTIS VACCINES & DIAGNOSTICPriority: May 14, 2004Filed: May 16, 2005Granted: Jul 6, 2010

Est. expiryMay 14, 2024(expired)· nominal 20-yr term from priority

Inventors:MASIGNANI VEGA ARICO BEATRICE MARIA

A61P 37/04A61P 37/00A61P 27/02A61P 31/04A61P 31/16A61P 31/12A61P 27/16A61P 31/00A61P 29/00A61P 11/04A61K 39/102A61P 13/00C07K 14/285A61K 2039/53A61K 2039/505A61P 11/02A61P 11/00A61P 19/02A61K 39/00

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Claims

Abstract

Polypeptides comprising non-typeable Haemophilus influenzae (NTHi) amino acid sequences. Over 2500 specific NTHi proteins are disclosed. The invention also provides related polypeptides, nucleic acids, antibodies and methods. These can all be used in medicine for treating or preventing disease and/or infection caused by H. influenzae , such as otitis media.

Claims

exact text as granted — not AI-modified

1. An isolated, immunogenic polypeptide comprising an amino acid sequence with at least 95% sequence identity to the sequence of SEQ ID NO:2368. 
     
     
       2. The polypeptide of  claim 1 , wherein said polypeptide comprises the amino acid sequence of SEQ ID NO:2368. 
     
     
       3. A composition comprising: (a) polypeptide of  claim 1 ; and (b) a pharmaceutically acceptable carrier. 
     
     
       4. The composition of  claim 3 , further comprising an adjuvant. 
     
     
       5. A composition comprising: (a) polypeptide of  claim 2 ; and (b) a pharmaceutically acceptable carrier. 
     
     
       6. The composition of  claim 5 , further comprising an adjuvant.

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