Artificial bone and joint compositions

Abstract

The present invention provides a ceramic porous body for in-vitro and in-vivo use comprising a composition comprising a calcium aluminate (CA) containing phase and optionally at least one of an accelerator, a retarder, a surfactant, a foaming agent, a reactive alumina, water, a fiber, and a biologically active material, and combinations thereof. Ceramic compositions are provides as well as method of using the ceramic compositions and methods of manufacturing a ceramic porous body. The ceramic porous bodies of this invention may be used as artificial bones, joints, in-vitro support structures, and in-vivo support structures for cells, tissues, organs, and nerve growth and regeneration.

1. A porous ceramic body for in vitro and in vivo use consisting essentially of a fired nonhydratable composition consisting essentially of;
 a calcium aluminate (CA) containing phase that is a single nonhydratable CA 6  phase, and a biologically active material that comprises at least one or more proteins for promoting bone growth, and a fiber, said CA 6  phase, said biologically active material and said fiber forming a ceramic body having interconnected porosity and that is chemically compatible with natural bone. 
 
     
     
       2. The porous ceramic body of  claim 1  having a porosity suitable for achieving vascularity. 
     
     
       3. The porous ceramic body of  claim 1  wherein said composition is capable of being functionalized for use with biologic processes. 
     
     
       4. The porous ceramic body of  claim 3  wherein said biological processes include accommodation of binding sites. 
     
     
       5. The porous ceramic body of  claim 1  wherein said composition is capable of being used to repair a bone void of a patient. 
     
     
       6. The porous ceramic body of  claim 1  that is selected from the group consisting of an artificial bone, artificial joint, in-vitro support structure, and in-vivo support structure. 
     
     
       7. The porous ceramic body of  claim 6  wherein said in-vitro and in-vivo support structures are a scaffold matrix for support of cell, tissue, organ and nerve growth.