Methods for inhibiting tumor cell growth

Abstract

The invention methods using a insulin-like growth factor receptor inhibitor to inhibit tumor cell growth in a subject in need thereof.

1. A method of inhibiting multiple myeloma cell growth in a subject comprising administering to said subject a cytotoxic or a chemotherapeutic agent and a composition comprising an insulin-like growth factor receptor-1 (IGF-1R) inhibitor, wherein said IGF-1R inhibitor is ADW-742 or NVP-AEW541. 
     
     
       2. The method of  claim 1 , wherein said composition is administered concomitantly with said agent. 
     
     
       3. The method of  claim 1 , wherein said composition is administered within 48 hours after said agent. 
     
     
       4. The method of  claim 1 , wherein said composition is administered within 24 hours after said agent. 
     
     
       5. The method of  claim 1 , wherein said composition is administered within 12 hours after said agent. 
     
     
       6. The method of  claim 1 , wherein said composition is administered within 3-12 hours after said agent. 
     
     
       7. The method of  claim 1 , wherein said composition is administered over a preselected period of time. 
     
     
       8. The method of  claim 7 , wherein said preselected period of time is about 1 to 2 days. 
     
     
       9. The method of  claim 1 , wherein the dose of said agent is sub-therapeutic. 
     
     
       10. The method of  claim 1 , wherein the dose of said IGF-1R inhibitor is sub-therapeutic. 
     
     
       11. The method of  claim 1 , wherein the dose of said IGF- 1 R inhibitor is in an amount sufficient to cause hyperglycemia, ketosis or glucosurioa. 
     
     
       12. The method of  claim 1 , wherein said chemotherapeutic agent is doxorubicin, melphalan or dexamethasone. 
     
     
       13. The method of  claim 1 , wherein said IGF-1R inhibitor is ADW-742. 
     
     
       14. The method of  claim 1 , wherein said IGF-1R inhibitor is NVP-AEW541.