Emergence of a R-type Ca2+ channel (Cav 2.3) contributes to cerebral artery constriction following subarachnoid hemorrhage

Abstract

The invention relates to methods and products for treatment of a neurological defect such as a subarachnoid hemorrhage or cerebral vasospasm. Specifically, R-type voltage-gated calcium channel inhibitors and related compositions and kits are described.

1. A method for treating a subject having cerebral vasospasm, comprising:
 administering to a subject having cerebral vasospasm an effective amount for treating cerebral vasospasm of a R-type voltage-dependent calcium channel inhibitor. 
 
     
     
       2. The method of  claim 1 , wherein the R-type voltage-dependent calcium channel inhibitor is an activity inhibitor. 
     
     
       3. The method of  claim 2 , wherein the activity inhibitor is a small molecule. 
     
     
       4. The method of  claim 2 , wherein the activity inhibitor is SNX-482.