Glucagon-like peptide-1 receptor agonists, the preparation and the use of the same

Abstract

The present invention provides the glucagon-like peptide-1 receptor agonists. It is indicated that the agonists have good binding capability to glucagon-like peptide-1 receptor by pharmacological tests. The present invention also provides the preparation of the agonists.

1. A glucagon-like peptide-1 receptor agonist having the following structural formula: 
       
         
           
           
               
               
           
         
       
       
         
           
           
               
               
           
         
         wherein Ar 1  is 
         wherein R 5  is alkyl; R 6  thenoyl; X 1 is O; X 2 is O, 
         wherein Ar 2  is 
       
       
         
           
           
               
               
           
         
         wherein R 2  is any one of the following substituent groups: alkanoyl; substituted alkanoyl which contains substituent groups including halogen, alkoxyl or hydroxyl; C 2 -C 6  enoyl; C 3 -C 6  cycloalkanoyl; benzoyl; substituted benzoyl which contains one, two or three substituent groups including alkoxyl and alkylamino; tert-butoxycarbonyl; adamantane formoxyl; and mandeloyl; and X 2  is NH; 
         X is O; and 
         Y is O. 
       
     
     
       2. The glucagon-like peptide-1 receptor agonist according to the  claim 1  having the following structural formula: