Compounds

Abstract

The present invention relates to compounds of general formula I wherein A, B, D, Y, R 1 , R 2 , R 3 , R 4 and R 5 are defined as in the specification, the enantiomers, the diastereomers, the mixtures and the salts thereof, particularly the physiologically acceptable salts thereof with organic or inorganic acids or bases, which have valuable properties, the preparation thereof, the pharmaceutical compositions containing the pharmacologically effective compounds, the preparation thereof and the use thereof.

1. A compound selected from the group consisting of: 
       
         
           
                 
                 
               
                     
                 
                   Ex- 
                     
                 
                   am- 
                     
                 
                   ple 
                   Structure 
                 
                     
                 
                   (53) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (54) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (55) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (56) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (57) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (58) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (59) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (60) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (61) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (62) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (63) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (64) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (65) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (66) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (67) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (68) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (69) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (70) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (71) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (72) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (73) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (74) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (75) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (76) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (77) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (78) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (79) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (80) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (81) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (82) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (102) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (103) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (104) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (105) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (106) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (107) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (108) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (109) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (110) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (111) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (112) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (113) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (114) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (115) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (116) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (117) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (318) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (319) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (320) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (321) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (322) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (323) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (325) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (326) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (327) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (328) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (329) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (330) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (331) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (332) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (333) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (334) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (335) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (336) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (337) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (338) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (339) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (340) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (341) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (342) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (343) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (344) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (345) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (346) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (347) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (348) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (349) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (350) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (351) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (352) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (353) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (354) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (355) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (356) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (357) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (358) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (359) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (360) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (361) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (362) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (363) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (364) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (365) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (366) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (367) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (368) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (369) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (370) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (371) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (372) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (373) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (374) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (375) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (376) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (377) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (378) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (379) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (380) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (381) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (382) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (383) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (384) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (385) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (386) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (387) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (388) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (389) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (390) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (391) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (392) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (393) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (394) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (395) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (396) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (397) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (398) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (399) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (400) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (401) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (402) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (403) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (404) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (405) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (406) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (407) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (408) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (409) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (410) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (411) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (412) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (413) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (414) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (415) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (416) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (417) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (419) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (420) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (423) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (425) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (426) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (427) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (428) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (429) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (430) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (431) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (432) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (433) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (434) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (435) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (436) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (437) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (438) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (439) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (440) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (441) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (442) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (443) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (444) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (445) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (448) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (449) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (450) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (451) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (452) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (453) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (454) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (455) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (456) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (457) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (458) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (459) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (460) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (461) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (462) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (463) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (464) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (465) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (466) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (467) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (468) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (470) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (471) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (472) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (473) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (474) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (475) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (476) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (477) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (478) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (479) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (480) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (481) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (482) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (575) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (576) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (577) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (578) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (579) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (580) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (581) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (582) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (583) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (584) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (586) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (587) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (588) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (590) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (591) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (592) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (615) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (616) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (618) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (619) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (620) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (621) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (622) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (623) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (624) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (625) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (626) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (627) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (628) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (629) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (630) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (638) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (639) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (640) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (641) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (642) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (643) 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
             
                
                
                
                
                
               
               
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
               
            
           
         
       
       or a physiologically acceptable salt thereof. 
     
     
       2. A pharmaceutical composition comprising a compound according to  claim 1  and a pharmaceutically acceptable carrier or diluent.