Substituted 8-[6-amino-3-pyridyl]xanthines

Abstract

The present invention provides substituted 8-[6-amino-3-pyridyl]xanthines like the compound shown in the following formula: and pharmaceutical compositions that are selective antagonists of A 2B adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.

1. A compound selected from the group: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
       2. A pharmaceutical composition comprising:
 (a) a therapeutically effective amount of a compound of  claim 1 ; and 
 (b) a pharmaceutically acceptable excipient. 
 
     
     
       3. A method for treating asthma comprising administering an effective amount of a compound  claim 1  to a mammal in need of such treatment. 
     
     
       4. A method for treating diabetic retinopathy, comprising administering an effective amount of a compound  claim 1  or a pharmaceutically acceptable salt thereof to a mammal in need of such treatment. 
     
     
       5. A compound of  claim 1 , wherein the compound is: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
       6. A compound of  claim 1 , wherein the compound is: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
       7. A compound of  claim 1 , wherein the compound is: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
       8. A compound of  claim 1 , wherein the compound is: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
       9. A con-mound of  claim 1 , wherein the compound is: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
       10. A compound of  claim 1 , wherein the compound is: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
       11. A compound of  claim 1 , wherein the compound is: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
       12. A compound of  claim 1 , wherein the compound is: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
       13. A compound of  claim 1 , wherein the compound is: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
       14. A compound of  claim 1 , wherein the compound is: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
       15. A compound of  claim 1 , wherein the compound is: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
       16. A pharmaceutical composition comprising:
 (a) a therapeutically effective amount of a compound of  claim 5 ; and 
 (b) a pharmaceutically acceptable excipient. 
 
     
     
       17. A pharmaceutical composition comprising:
 (a) a therapeutically effective amount of a compound of  claim 6 ; and 
 (b) a pharmaceutically acceptable excipient. 
 
     
     
       18. A pharmaceutical composition comprising:
 (a) a therapeutically effective amount of a compound of  claim 7 ; and 
 (b) a pharmaceutically acceptable excipient. 
 
     
     
       19. A pharmaceutical composition comprising:
 (a) a therapeutically effective amount of a compound of  claim 8 ; and 
 (b) a pharmaceutically acceptable excipient. 
 
     
     
       20. A pharmaceutical composition comprising:
 (a) a therapeutically effective amount of a compound of  claim 9 ; and 
 (b) a pharmaceutically acceptable excipient. 
 
     
     
       21. A pharmaceutical composition comprising:
 (a) a therapeutically effective amount of a compound of  claim 10 ; and 
 (b) a pharmaceutically acceptable excipient. 
 
     
     
       22. A pharmaceutical composition comprising:
 (a) a therapeutically effective amount of a compound of  claim 11 ; and 
 (b) a pharmaceutically acceptable excipient. 
 
     
     
       23. A pharmaceutical composition comprising:
 (a) a therapeutically effective amount of a compound of  claim 12 ; and 
 (b) a pharmaceutically acceptable excipient. 
 
     
     
       24. A pharmaceutical composition comprising:
 (a) a therapeutically effective amount of a compound of  claim 13 ; and 
 (b) a pharmaceutically acceptable excipient. 
 
     
     
       25. A pharmaceutical composition comprising:
 (a) a therapeutically effective amount of a compound of  claim 14 ; and 
 (b) a pharmaceutically acceptable excipient. 
 
     
     
       26. A pharmaceutical composition comprising:
 (a) a therapeutically effective amount of a compound of  claim 15 ; and 
 (b) a pharmaceutically acceptable excipient. 
 
     
     
       27. A method for treating asthma, comprising: administering an effective amount of a compound  claim 5  to a mammal in need of such treatment. 
     
     
       28. A method for treating asthma, comprising: administering an effective amount of a compound  claim 6  to a mammal in need of such treatment. 
     
     
       29. A method for treating asthma, comprising: administering an effective amount of a compound  claim 7  to a mammal in need of such treatment. 
     
     
       30. A method for treating asthma, comprising: administering an effective amount of a compound  claim 8  to a mammal in need of such treatment. 
     
     
       31. A method for treating asthma, comprising: administering an effective amount of a compound  claim 9  to a mammal in need of such treatment. 
     
     
       32. A method for treating asthma, comprising: administering an effective amount of a compound  claim 10  to a mammal in need of such treatment. 
     
     
       33. A method for treating asthma, comprising: administering an effective amount of a compound  claim 11  to a mammal in need of such treatment. 
     
     
       34. A method for treating asthma, comprising: administering an effective amount of a compound  claim 12  to a mammal in need of such treatment. 
     
     
       35. A method for treating asthma, comprising: administering an effective amount of a compound  claim 13  to a mammal in need of such treatment. 
     
     
       36. A method for treating asthma, comprising: administering an effective amount of a compound  claim 14  to a mammal in need of such treatment. 
     
     
       37. A method for treating asthma, comprising: administering an effective amount of a compound  claim 15  to a mammal in need of such treatment. 
     
     
       38. A method for treating diabetic retinopathy, comprising: administering an effective amount of a compound  claim 5  to a mammal in need of such treatment. 
     
     
       39. A method for treating diabetic retinopathy, comprising: administering an effective amount of a compound  claim 6  to a mammal in need of such treatment. 
     
     
       40. A method for treating diabetic retinopathy, comprising: administering an effective amount of a compound  claim 7  to a mammal in need of such treatment. 
     
     
       41. A method for treating diabetic retinopathy, comprising: administering an effective amount of a compound  claim 8  to a mammal in need of such treatment. 
     
     
       42. A method for treating diabetic retinopathy, comprising: administering an effective amount of a compound  claim 9  to a mammal in need of such treatment. 
     
     
       43. A method for treating diabetic retinopathy, comprising: administering an effective amount of a compound  claim 10  to a mammal in need of such treatment. 
     
     
       44. A method for treating diabetic retinopathy, comprising: administering an effective amount of a compound  claim 11  to a mammal in need of such treatment. 
     
     
       45. A method for treating diabetic retinopathy, comprising: administering an effective amount of a compound  claim 12  to a mammal in need of such treatment. 
     
     
       46. A method for treating diabetic retinopathy, comprising: administering an effective amount of a compound  claim 13  to a mammal in need of such treatment. 
     
     
       47. A method for treating diabetic retinopathy, comprising: administering an effective amount of a compound  claim 14  to a mammal in need of such treatment. 
     
     
       48. A method for treating diabetic retinopathy, comprising: administering an effective amount of a compound  claim 15  to a mammal in need of such treatment.