Use of neuronal sodium channel antagonists for the control of ectoparasites in homeothermic animals

Abstract

The present invention provides an effective method and composition for the prevention, amelioration or control of external parasites on a human or animal via the administration of a prophylactically, therapeutically or pharmaceutically effective amount of a neuronal sodium channel antagonist to a human or animal in need thereof.

1. An ectoparisiticidal composition which comprises a pharmaceutically acceptable carrier and about 20% w/v of a neuronal sodium channel antagonist which is a compound of the formula: 
       
         
           
           
               
               
           
         
       
       together with about 10% w/v of amitraz, about 20% w/v of isopropyl myristate and about 10% cineole in diethyl toluamide, wherein each w/v % indicates weight in relation to the total volume of the composition. 
     
     
       2. An ectoparisiticidal composition which comprises a pharmaceutically acceptable carrier and about 20% w/v of a neuronal sodium channel antagonist which is a compound of the formula: 
       
         
           
           
               
               
           
         
       
       together with about 10% w/v of amitraz, in isopropyl myristate, wherein each w/v % indicates weight in relation to the total volume of the composition. 
     
     
       3. An ectoparisiticidal composition which comprises a pharmaceutically acceptable carrier and about 30% w/v of:
 amitraz and a neuronal sodium channel antagonist which is a compound of the formula: 
 
       
         
           
           
               
               
           
         
       
       wherein the about 30% w/v is the combined weight of amitraz and the neuronal sodium channel antagonist in relation to the total volume of the composition. 
     
     
       4. The ectoparisiticidal composition of  claim 3 , further comprising diethyl toluamide. 
     
     
       5. The ectoparasiticidal composition of  claim 3 , further comprising cineole. 
     
     
       6. The ectoparasiticidal composition of  claim 5 , wherein the cineole is present at about 10% w/v in relation to the total volume of the composition. 
     
     
       7. The ectoparasiticidal composition of  claim 3 , wherein the carrier comprises a lower alkyl ketone or an ester. 
     
     
       8. The ectoparasiticidal composition of  claim 7 , wherein the lower alkyl ketone or the ester is present at about 30% to about 60% w/v in relation to the total volume of the composition. 
     
     
       9. The ectoparasiticidal composition of  claim 3 , wherein the carrier comprises a spreading agent. 
     
     
       10. The ectoparasiticidal composition of  claim 3 , wherein the spreading agent is isopropyl myristate.