US7928200B1ExpiredUtility

Human genes relating to respiratory diseases and obesity

70
Assignee: OSCIENT PHARMACEUTICALS CORPPriority: Jul 30, 1999Filed: Jul 25, 2008Granted: Apr 19, 2011
Est. expiryJul 30, 2019(expired)· nominal 20-yr term from priority
Inventors:Tim KeithRandall LittlePaul Van EerdeweghJosée DupuisRichard Del MastroJason SimonKristina AllenSunil Pandit
C07K 16/18A61P 11/06C07K 2317/24C07K 14/47
70
PatentIndex Score
0
Cited by
32
References
26
Claims

Abstract

This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.

Claims

exact text as granted — not AI-modified
1. An isolated antibody or epitope-binding fragment thereof which specifically binds to a polypeptide comprising the amino acid sequence set forth in SEQ ID NO:11 wherein the specific binding is to the SEQ ID NO:11 portion of the polypeptide. 
     
     
       2. The isolated antibody or epitope-binding fragment of  claim 1 , which binds to an immunogenic component comprising at least 30 consecutive amino acid residues of SEQ ID NO:11. 
     
     
       3. The isolated antibody or epitope-binding fragment of  claim 1 , which binds to an immunogenic component comprising at least 50 consecutive amino acid residues of SEQ ID NO:11. 
     
     
       4. The isolated antibody or epitope-binding fragment of  claim 1 , which binds to an immunogenic component comprising at least 100 consecutive amino acid residues of SEQ ID NO:11. 
     
     
       5. The isolated antibody or epitope-binding fragment of  claim 1  which binds to a polypeptide having an amino acid sequence of at least 200 consecutive residues of SEQ ID NO:11 or an immunogenic component thereof. 
     
     
       6. The isolated antibody or epitope-binding fragment of  claim 1 , which is immobilized on a solid support. 
     
     
       7. The isolated antibody or epitope-binding fragment of  claim 1 , which binds to a polypeptide having an amino acid sequence of SEQ ID NO: 11. 
     
     
       8. The isolated antibody or epitope-binding fragment of  claim 1  which is a monoclonal antibody. 
     
     
       9. The isolated antibody or epitope-binding fragment of  claim 1  which is a polyclonal antibody. 
     
     
       10. The isolated antibody or epitope-binding fragment of  claim 1  which is a recombinant antibody. 
     
     
       11. The isolated antibody or epitope-binding fragment of  claim 1  which is a chimeric antibody. 
     
     
       12. The isolated antibody or epitope-binding fragment of  claim 1  which is a humanized antibody. 
     
     
       13. The isolated antibody or epitope-binding fragment of  claim 1  bound to said polypeptide. 
     
     
       14. A composition comprising the isolated antibody or epitope-binding fragment of  claim 1  and a pharmaceutically acceptable carrier. 
     
     
       15. An isolated antibody or epitope-binding fragment thereof which specifically binds to a polypeptide comprising the an amino acid sequence encoded by 50 or more consecutive nucleotides of SEQ ID NO:10 wherein the specific binding is to the amino acid sequence encoded by 50 or more consecutive nucleotides of SEQ ID NO:10 portion of the polypeptide. 
     
     
       16. The isolated antibody or epitope-binding fragment of  claim 15 , which binds to an immunogenic component comprising at least 30 amino acid residues encoded by consecutive nucleotides of SEQ ID NO:10. 
     
     
       17. The isolated antibody or epitope-binding fragment of  claim 15 , which binds to an immunogenic component comprising at least 50 amino acid residues encoded by consecutive nucleotides of SEQ ID NO:10. 
     
     
       18. The isolated antibody or epitope-binding fragment of  claim 15 , which binds to an immunogenic component comprising at least 100 amino acid residues encoded by consecutive nucleotides of SEQ ID NO:10. 
     
     
       19. The isolated antibody or epitope-binding fragment of  claim 15 , which is immobilized on a solid support. 
     
     
       20. The isolated antibody or epitope-binding fragment of  claim 15  which is a monoclonal antibody. 
     
     
       21. The isolated antibody or epitope-binding fragment of  claim 15  which is a polyclonal antibody. 
     
     
       22. The isolated antibody or epitope-binding fragment of  claim 15  which is a recombinant antibody. 
     
     
       23. The isolated antibody or epitope-binding fragment of  claim 15  which is a chimeric antibody. 
     
     
       24. The isolated antibody or epitope-binding fragment of  claim 15  which is a humanized antibody. 
     
     
       25. The isolated antibody or epitope-binding fragment of  claim 15  bound to said polypeptide. 
     
     
       26. A composition comprising the isolated antibody or epitope-binding fragment of  claim 15  and a pharmaceutically acceptable carrier.

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