Methods of enhancing the immune response to autoantigens in mucosal associated lymphatic tissue

Abstract

Co-administration of an effective amount of autoantigen and UV light to mucosal associated lymphatic tissue (MALT) in a patient.

1. A method of inducing tolerance to an antigen in a mammal, comprising the steps of:
 a) irradiating nasal associated lymphatic tissue (NALT) in the mammal with an effective amount of UV light, and 
 b) nasally administering an effective amount of the antigen to the mammal, wherein the antigen is E-selectin administered in an amount effective to inhibit the development of ischemic and hemorrhagic stroke. 
 
     
     
       2. The method of  claim 1  wherein the e-selectin is provided intranasally in an amount of between 0.5 μg and 50 mg per administration. 
     
     
       3. The method of  claim 1  wherein the e-selectin is provided intranasally in an amount of between 5 μg and 5 mg per administration. 
     
     
       4. The method of  claim 1  wherein the e-selectin is provided between about 3 and 10 times.