Hydrate for medical purposes

Abstract

The present invention relates to [7-[(7S)-7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-8-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hemihydrate. This hemihydrate is stable and easy to prepare, and has excellent properties for a pharmaceutical bulk powder.

1. 7-[(7S)-7-amino-7-methyl-5-azaspiro[2.4]heptan -5-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-8-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hemihydrate. 
     
     
       2. A compound represented by the following formula: 
       
         
           
           
               
               
           
         
       
     
     
       3. A pharmaceutical composition comprising the compound according to  claim 1  and a pharmaceutically acceptable carrier. 
     
     
       4. A method for treating tuberculosis or preventing or treating a bacterial infection, comprising administering to a patient in need thereof an effective amount of the compound according to  claim 1  to treat or prevent tuberculosis or a bacterial infection in the patient. 
     
     
       5. The method according to  claim 4 , wherein tuberculosis is treated. 
     
     
       6. The method according to  claim 4 , wherein a bacterial infection is treated or prevented. 
     
     
       7. A pharmaceutical composition comprising the compound according to  claim 2  and a pharmaceutically acceptable carrier. 
     
     
       8. A method for treating tuberculosis or preventing or treating a bacterial infection, comprising administering to a patient in need thereof an effective amount of the compound according to  claim 2  to treat or prevent tuberculosis or a bacterial infection in the patient. 
     
     
       9. The method according to  claim 8 , wherein tuberculosis is treated. 
     
     
       10. The method according to  claim 8 , wherein a bacterial infection is treated or prevented. 
     
     
       11. The method according to  claim 4 , wherein tuberculosis or a bacterial infection is treated. 
     
     
       12. The method according to  claim 8 , wherein tuberculosis or a bacterial infection is treated. 
     
     
       13. The method according to  claim 4 , wherein a bacterial infection is prevented. 
     
     
       14. The method according to  claim 8 , wherein a bacterial infection is prevented.