US8058483B2ActiveUtilityA1
Composition of matter containing harmonized hydroxyl modified fullerene substance
Est. expiryFeb 2, 2027(~0.6 yrs left)· nominal 20-yr term from priority
Inventors:Djuro Koruga
A61P 31/22A61P 43/00A61P 35/00A61P 29/00A61P 25/28C01B 5/00A61P 17/00A61K 31/375A61K 9/08A61P 17/12A61K 8/19C02F 1/48C07C 35/44A61P 17/02C07C 2604/00A61Q 19/00C02F 1/005C02F 1/30A61P 17/10A61K 8/671
70
PatentIndex Score
3
Cited by
2
References
19
Claims
Abstract
The present invention provides a composition of matter having a harmonized form (Φ/φ) of a hydroxyl modified fullerene having a molecular formula of C 60 (OH)xH y ∀ z (where x is from 10 to 36, and y is from 0 to 24 and z is from 0 to 12) the composition of matter having substantially the same 13 C NMR spectra shown in FIG. 8 having a dominant peak at 170.2 ppm. This peak shows that each carbon atom of C 60 is equally covered by OH groups and that the system [C 60 (OH)xH y ∀ z ] (Φ/φ is one body entity.
Claims
exact text as granted — not AI-modified1. A composition of matter comprising a harmonized (Φ/φ) form of a hydroxyl modified fullerene having a molecular formula of C 60 (OH) x H y ∀ z (where x is from 10 to 36, and y is from 0 to 24 and z is from 0 to 12 the composition of matter having a 13 C NMR spectra having a dominant peak at 170.2 ppm.
2. The composition of matter of claim 1 ([C 60 (OH)xH y ∀ z ] (Φ/φ) ) wherein the composition has a remanent magnetism differing from a remanent magnetism of a non-harmonized C 60 (OH)xH y ∀ z (where x is from 10 to 36, and y is from 0 to 24 and z is from 0 to 12) by about 4 nT.
3. The composition of matter of claim 1 having a molecular formula of [C 60 (OH) 24 ] (Φ/φ) .
4. The composition of matter of claim 1 having a first hydrated form with an intermolecular formula [C 60 (OH) 24 ] (Φ/φ) .n(H 2 O).
5. The composition of matter of claim 1 having a second hydrated form with an intermolecular formula {[C 60 (OH) 24 ] (Φ/φ) .n(H 2 O)}m(H 2 O).
6. The composition of matter of claim 1 having a molecular formula of [C 60 (OH) 24 ] (Φ/φ) and intermolecular formula {[C 60 (OH) 24 ] (Φ/φ) .n(H 2 O)} p(Na + , Cl − , Mg 2+ , Ca 2+ , and other ions), when n-water molecules are in one, two or three layers, and p− ions in different concentration from 0.01% to 15%.
7. The composition of matter of claim 1 having an intermolecular formula {[C 60 (OH) 24 ] (Φ/φ) .n(H 2 O).p(Na + , Cl − , Mg 2+ , Ca 2+ , and other ions).m(H 2 O).
8. The composition of matter of claim 1 is not cytotoxic when measured by an Ames test.
9. A biologically effective composition comprising:
a harmonized form of a hydroxyl modified fullerene having a molecular formula of C 60 (OH)xH y ∀ z (where x is from 10 to 36, and y is from 0 to 24 and z is from 0 to 12) from 1 to 20% by weight of the composition; and
a carrier in an amount by weight of from 80% to 99% by weight of the composition.
10. The composition of claim 9 wherein the carrier is selected from the group consisting of aqua purificate, propylene glycol, isopropyl isostearate, caprylic/capric triglyceride, butyrospermum parkii (Shea Butter), C12-20 acid PEG-8 ester, butyl methoxydibenzoylmethane, squalane, DEA-cetil phosphate, carbomer, simmondisia chinensis (Jojoba) seed oil, echinacea angustifolia extract, parfum, phenoxyethanol, methylparaben, propylparaben, ethylparaben, butylparaben, isobutylparaben, PEG-8, tocopherol, ascorbyl palmitate, ascorbic acid, citric acid, hydrolyzed serum protein, hydrolized yeast protein, pyridoxine, niacinamide, panthenol, allantoin, biotin, Vitamin C, Vitamin E, Vitamin A, sodium sydrocside, sodium, potassium, magnesium, zinc, cobalt, iron, chloride/sulfate, pentylene glycol, glycerin, propylene glycol, carbomer, and sodium hydroxide.
11. The composition of claim 9 wherein the carrier is suitable for pharmaceutical, medical or cosmetic usage.
12. The composition of claim 9 further comprising a therapeutic substance.
13. The composition of claim 11 wherein the therapeutic substance is selected from the group consisting of vitamins, hormones, peptides, polypeptides, pharmaceutically active compounds, proteins, minerals, electrolytes.
14. The composition of claim 12 wherein the therapeutic substance is Vitamin C.
15. An aqueous solution containing Vitamin C and having an enhanced shelf life comprising:
from 1%-7.5% by weight of Vitamin C in water; and
from 10%-25.5% by weight of harmonized, hydroxyl modified fullerene having a molecular formula of [C 60 (OH)xH y ∀ z ] (Φ/φ (where x is from 10 to 36, and y is from 0 to 24 and z is from 0 to 12).
16. The solution of claim 15 further comprising an additive selected from the group of coenzyme Q10, vitamin A, vitamin E, proline, silver nanoparticulate, gold nanoparticulate, zinc oxide nanoparticulate, titanium dioxide nanoparticulate, active carbon micro- and nanoparticulate, and any type of icosohedral fullerenes.
17. The solution of claim 16 wherein the additive is EDTA.
18. The solution of claim 17 wherein the solution contains in excess of 70% by weight of active Vitamin C after 28 days of storage.
19. A biologically effective composition comprising:
a harmonized form of a hydroxyl modified fullerene having a molecular formula of C 60 (OH)xH y ∀ z (where x is from 10 to 36, and y is from 0 to 24 and z is from 0 to 12) for homeopathic pharmacy in concentration from 10 −4 to 10 −20000 , or according to centesimal potency from 2 cH to 10 M.Cited by (0)
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