Pharmacological treatments for sleep disorders (apnoe) with prostanoid receptor antagonists

Abstract

This invention is directed to methods for preventing or ameliorating sleep-related breathing disorders. The method comprises administration to a patient in need thereof an effective dose of one or a combination of prostanoid receptor antagonists (eg. ramatroban, ifetroban, diphloretin, phosphate, polyphloretin phosphate, seratrodast, SC19220). The prostanoid receptor antagonist or combination of prostanoid receptor antagonists can be administered in conjunction with one or more serotonin receptor agonists, one or more cannabinoids receptor agonists, one or more serotonin reuptake inhibitors, one or more noradrenalin reuptake inhibitors, a combination of reuptake inhibitors, an inhibitor of prostanoid synthesis, or any combination of the foregoing.

1. A method for ameliorating a sleep-related breathing disorder, the method comprising the step of administering an effective dose of one or more prostanoid receptor antagonists to a patient in need thereof, wherein said prostanoid receptor antagonist is selected from the group consisting of ramatroban, ifetroban, seratrodast, diphloretin phosphate, polyphloretin phosphate, or SC19220.