Pharmaceutical formulation for treating tinea of feet and hands and preparation thereof

Abstract

A pharmaceutical formulation for treating tinea of feet and hands is disclosed, which is composed of Fructus Gleditsia, Alumen and Borneol. Also disclosed is a cream preparative method of the pharmaceutical formulation, which comprises Fructus Gleditsia is decocted with water, and the decocted liquid is dried under decompression into powder, which is formulated to a cream together with the powders of Alumen and Borneol as well as the respective excipients.

1. A pharmaceutical formulation for the treatment of tinea of feet and hands, which is composed of preparations in following weight ratios:
 Fructus Gleditsia 55%-65%, Borneol 8%-15%, Alumen 15%-30%. 
 
     
     
       2. The pharmaceutical formulation for the treatment of tinea of feet and hands according to  claim 1 , wherein the weight ratios are:
 Fructus Gleditsia 62.5%, Borneol 12.5%, Alumen 25%. 
 
     
     
       3. The pharmaceutical formulation for the treatment of tinea of feet and hands according to  claim 1 , wherein the pharmaceutical formulation is prepared into an effective dosage form. 
     
     
       4. A cream preparation method of pharmaceutical formulation for the treatment of tinea of feet and hands, comprising steps of:
 (1) Providing 200 grams of Fructus Gleditsia powder into six-fold water by weight and decocting it for 1.5 hours to provide a first decocted liquid, and then collecting said first decocted liquid; 
 (2) (a) Adding five-fold water by weight into said first decocted liquid, and decocting it for 1.5 hours to provide a second decocted liquid, and collecting said second decocted liquid; 
 (2) (b) Adding five-fold water by weight into said second decocted liquid, and decocting it for 1.5 hours to provide a third decocted liquid, and then collecting said third decocted liquid; 
 (3) (a) Concentrating the third decocted liquid under reduced pressure into a liquid with relative density of 1.10-1.15 at 80° C. to provide a fourth decocted liquid; 
 (3)(b) Adding sufficient amount of ethanol to said fourth decocted liquid to make the concentration of ethanol reach 60%, stirring adequately and then leaving it still for 24 hours to provide an ethanol-containing solution; 
 (3)(c) Filtering said ethanol-containing solution, removing the ethanol from the solution, and then concentrating under reduced pressure into a liquid with relative density of 1.30-1.35 at 80° C., then drying the liquid under reduced pressure to provide a first powder; 
 (4) Providing and mixing 80 gram of Alumen and 40 gram of Borneol to provide a second powder; and 
 (5) Heating a water phase composed of 4.5 ml TEA, 25 grams of Tween-80, 100 ml glycerol and water and an oil phase composed of 50 gram of stearic acid, 35 grams of liquid paraffin, 30 grams of Vaseline and 35 grams of glyceryl monostearate to a temperature of 80° C. and keeping it at this temperature, then putting the oil phase into water phase and continuously stirring and keeping it at 80° C. for 15 minutes, cooling it down to the temperature of 40° C., adding said first powder and said second powder to provide a mixture, stirring said mixture to room temperature to obtain a pharmaceutical formulation for the treatment of tinea of feet and hands in cream preparation form.