US8168804B2ActiveUtilityA1

Large stoke shift NIR dyes

71
Assignee: PHAM WELLINGTONPriority: Jun 29, 2007Filed: Jun 30, 2008Granted: May 1, 2012
Est. expiryJun 29, 2027(~1 yrs left)· nominal 20-yr term from priority
A61K 49/0032A61K 49/0056A61K 49/0021C09B 23/0041C09B 23/0066C07D 209/14C09B 23/086C07D 403/14
71
PatentIndex Score
2
Cited by
32
References
8
Claims

Abstract

A compound of the following formula: wherein R 1 is SO 3 H; R 2 is chosen from carboxylic acid group and SO 3 H; and R 3 is chosen from Cl, carboxylic acid group, amino, amino-carboxylic acid group, amido group, amino-amido group, and methods of use related to imaging.

Claims

exact text as granted — not AI-modified
1. A compound of the following formula: 
       
         
           
           
               
               
           
         
       
       wherein R 1  is SO 3 H; R 2  is chosen from carboxylic acid group and SO 3 H; and R 3  is chosen from: 
       
         
           
           
               
               
           
         
       
       an amino-succinimidyl ester group, or an amino-maleimide group 
     
     
       2. The compound of  claim 1 , wherein R 1  and R 2  are SO 3 H. 
     
     
       3. The compound of  claim 1 , wherein R 3  is: 
       
         
           
           
               
               
           
         
       
     
     
       4. The compound of  claim 1 , wherein R 3  is: 
       
         
           
           
               
               
           
         
       
     
     
       5. The compound of  claim 1 , wherein R 3  is 
       
         
           
           
               
               
           
         
       
     
     
       6. The compound of  claim 1 , wherein R 3  is chosen from an amino-succinimidyl ester group and an amino-maleimide group. 
     
     
       7. A compound of  claim 1  of the following formula: 
       
         
           
           
               
               
           
         
       
     
     
       8. A compound of  claim 1  of the following formula:

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