Compositions and methods for treating, reducing, ameliorating, or preventing infections

Abstract

Compositions for treating, reducing, ameliorating, or preventing infections comprise a fluoroquinolone having Formulae I-VIII and an additional anti-infective agent. Methods for treating, reducing, ameliorating, or preventing such infection use such compositions. Such compositions and methods can be effective against mixed types of pathogens including certain antibiotic-resistant microbial pathogens found in such infections.

1. A method for treating, reducing, or ameliorating a bacterial infection in a subject, the method comprising administering to a subject in need thereof, a synergistic composition comprising: (a) a fluoroquinolone having Formula IV or salts thereof; and (b) ciprofloxacin; wherein Formula IV is 
       
         
           
           
               
               
           
         
       
       and wherein each of the compound having Formula IV and ciprofloxacin is present in the composition at a concentration in the range from 0.0001% to 10% by weight of the composition. 
     
     
       2. The method of  claim 1 , wherein the composition is administered topically, orally, or systemically. 
     
     
       3. The method of  claim 2 , wherein the composition is administered topically. 
     
     
       4. The method of  claim 3 , wherein the infection is an infection of an eye, an ear, a portion of a respiratory system, or a combination thereof. 
     
     
       5. The method of  claim 1 , wherein the composition further comprises an additional anti-infective agent selected from the group consisting of antiviral agents, antifungal agents, antiprotozoal agents, antibacterial agents other than the fluoroquinolone having Formula IV and ciprofloxacin, and combinations thereof. 
     
     
       6. The method of  claim 5 , wherein said infection is caused by a bacterium and a fungus, and said additional anti-infective agent is an antifungal drug. 
     
     
       7. The method of  claim 5 , wherein said infection is caused by a bacterium and a virus, and said additional anti-infective agent is an antiviral drug. 
     
     
       8. The method of  claim 5 , wherein said infection is caused by a bacterium and a protozoa, and said additional anti-infective agent is an antiprotozoal drug.