HSP90 inhibitor

Abstract

Compounds represented by formula (1) shown below, pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising such compounds are provided.

1. A compound represented by formula (4) or a pharmaceutically acceptable salt thereof: 
       
         
           
           
               
               
           
         
         wherein,
 A represents O or S; 
 X represents CH or N; 
 Y represents O or S; 
 Z represents an optionally substituted C 1-10  alkyl group, an optionally substituted C 2-10  alkenyl group, an optionally substituted C 2-10  alkynyl group, an optionally substituted C 3-10  cycloalkyl group, an optionally substituted C 6-12  aryl group, an optionally substituted 5- to 12-membered heteroaryl group, or an optionally substituted 3- to 12-membered heterocycle; 
 n is an integer from 0 to 2; and 
 R 1  represents a hydrogen atom, halogen atom, cyano group, C 1-6  alkyl group, C 1-4  haloalkyl group, C 2-6  alkenyl group, C 2-6  alkynyl group, C 1-6  alkoxy group, or C 1-6  alkylthio group. 
 
       
     
     
       2. The compound or a pharmaceutically acceptable salt thereof according to  claim 1 , wherein R 1  is a halogen atom, C 1-4  alkyl group or C 1-4  haloalkyl group. 
     
     
       3. The compound or a pharmaceutically acceptable salt thereof according to  claim 2 , wherein R 1  is a chlorine atom. 
     
     
       4. The compound or a pharmaceutically acceptable salt thereof according to  claim 2 , wherein R 1  is a methyl group. 
     
     
       5. The compound or a pharmaceutically acceptable salt thereof according to  claim 1 , wherein R 1  is a halogen atom. 
     
     
       6. The compound or a pharmaceutically acceptable salt thereof according to  claim 1 , wherein Z is a substituted C 1-10  alkyl group, a substituted C 3-10  cycloalkyl group, a substituted C 2-10  alkenyl group, a substituted C 2-10  alkynyl group, a substituted C 6-12  aryl group, a substituted 5- to 12-membered heteroaryl group, or a substituted 3- to 12-membered heterocycle. 
     
     
       7. The compound or a pharmaceutically acceptable salt thereof according to  claim 6 , wherein Z is a substituted C 1-10  alkyl group, a substituted C 6-12  aryl group, or a substituted 3- to 12-membered heterocycle. 
     
     
       8. The compound or a pharmaceutically acceptable salt thereof according to  claim 7 , wherein the substituent in Z is a hydroxyl group, oxo group, a group represented by formula (5): 
       
         
           
           
               
               
           
         
         wherein R 10  and R 11  are the same or different, and represent a hydrogen atom, an optionally substituted C 1-6  alkyl group, an optionally substituted C 1-6  alkenyl group, or an optionally substituted C 1-6  alkynyl group, or R 10  and R 11  together form an optionally substituted 3- to 12-membered heterocycle; 
         a group represented by formula (6): 
       
       
         
           
           
               
               
           
         
         wherein R 12  and R 13  are the same or different, and represent a hydrogen atom, an optionally substituted C 1-6  alkyl group, an optionally substituted C 1-6  alkenyl group, or an optionally substituted C 1-6  alkynyl group, or an optionally substituted 5- to 12-membered heteroaryl group, or R 12  and R 13  are taken together to form an optionally substituted 3- to 12-membered heterocycle; 
         a group represented by the formula (34): 
       
       
         
           
           
               
               
           
         
         wherein R 14  and R 15  are the same or different, and represent a hydrogen atom, an optionally substituted C 1-6  alkyl group, an optionally substituted C 1-6  alkenyl group, or an optionally substituted C 1-6  alkynyl group, or R 14  and R 15  are taken together to form an optionally substituted 3- to 12-membered heterocycle; 
         a group represented by formula (35): 
       
       
         
           
           
               
               
           
         
         wherein R 16  represents an optionally substituted C 1-6  alkyl group, an optionally substituted C 1-6  alkenyl group, or an optionally substituted C 1-6  alkynyl group; or 
         a group represented by formula (36): 
       
       
         
           
           
               
               
           
         
         wherein R 17  represents a hydrogen atom, an optionally substituted C 1-6  alkyl group, an optionally substituted C 1-6  alkenyl group, or an optionally substituted C 1-6  alkynyl group. 
       
     
     
       9. The compound or a pharmaceutically acceptable salt thereof according to  claim 8 , wherein the substituent in Z is a hydroxyl group, oxo group, a group represented by formula (5): 
       
         
           
           
               
               
           
         
         wherein R 10  is a hydrogen atom; and R 11  is an optionally substituted C 1-6  alkyl group; 
         a group represented by formula (6): 
       
       
         
           
           
               
               
           
         
         wherein R 12  and R 13  are the same or different, and represent a hydrogen atom, or an optionally substituted C 1-6  alkyl group; 
         a group represented by formula (34): 
       
       
         
           
           
               
               
           
         
         wherein R 14  and R 15  are hydrogen atoms; 
         a group represented by formula (35): 
       
       
         
           
           
               
               
           
         
         wherein R 16  represents a C 1-6  alkyl group; or 
         a group represented by formula (36): 
       
       
         
           
           
               
               
           
         
         wherein R 17  represents a hydrogen atom. 
       
     
     
       10. The compound or a pharmaceutically acceptable salt thereof according to  claim 1 , wherein X is CH. 
     
     
       11. The compound or a pharmaceutically acceptable salt thereof according to  claim 1 , wherein Y is S. 
     
     
       12. A compound or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of:
 (71): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(2-methoxyphenylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (72): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(2-chlorophenylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (73): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(3-chlorophenylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (74): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(4-chlorophenylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (75): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(4-methylsulfanyl-phenylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (76): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(3-methoxyphenylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (77): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(4-methoxyphenylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (78): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(2,5-difluorophenylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (79): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(2-fluorophenylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (80): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(4-fluorophenylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (81): 4-(2-bromophenoxy)-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylamine; 
 (82): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(3,4-dimethoxyphenoxy)-[1,3,5]triazin-2-ylamine; 
 (83): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(3,5-dimethoxyphenoxy)-[1,3,5]triazin-2-ylamine; 
 (84): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(1H-imidazol-2-ylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (85): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(naphthalen-1-ylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (86): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(naphthalen-2-ylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (87): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(3,4-dimethoxy-phenylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (88): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(3-trifluoromethoxyphenylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (89): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(4-trifluoromethoxyphenylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (90): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(2,5-dichlorophenylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (91): 4-(2-bromophenylsulfanyl)-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylamine; 
 (92): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-cyclohexylsulfanyl-[1,3,5]triazin-2-ylamine; 
 (93): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-isobutylsulfanyl-[1,3,5]triazin-2-ylamine; 
 (94): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-isopropylsulfanyl-[1,3,5]triazin-2-ylamine; 
 (95): N-{4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-phenyl}-acetamide; 
 (96): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(4-methoxybenzylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (97): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(3-chlorobenzyloxy)-[1,3,5]triazin-2-ylamine; 
 (98): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(3-methoxyphenoxy)-[1,3,5]triazin-2-ylamine; 
 (99): {4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-yloxy]-phenyl}-methanol; 
 (100): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(4-methoxyphenoxy)-[1,3,5]triazin-2-ylamine; 
 (101): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(2-methoxyphenoxy)-[1,3,5]triazin-2-ylamine; 
 (102): N-{3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-yloxy]-phenyl}-acetamide; 
 (103): 2-{3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-yloxy]-phenyl}-ethanol; 
 (104): {3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-yloxy]-phenyl}-urea; 
 (105): 4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-phenol; 
 (106): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(4-nitrophenylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (107): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(2-methyl-furan-3-ylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (108): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(2,5-dimethoxyphenoxy)-[1,3,5]triazin-2-ylamine; 
 (109): 4-(3-aminophenylsulfanyl)-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylamine; 
 (110): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-propylsulfanyl-[1,3,5]triazin-2-ylamine; 
 (111): [4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-acetic acid methyl ester; 
 (112): [4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-acetic acid; 
 (113): N-{2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-acetamide; 
 (114): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(2-dimethylaminoethylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (115): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propan-1-ol; 
 (116): 1-(4-{3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-yloxy]-phenyl}-piperazin-1-yl)-ethanone; 
 (117): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-phenol: 
 (118): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-o tolylsulfanyl-[1,3,5]triazin-2-ylamine; 
 (119): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-acetamide; 
 (120): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(2-methoxybenzyloxy)-[1,3,5]triazin-2-ylamine; 
 (121): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(3-methoxybenzyloxy)-[1,3,5]triazin-2-ylamine; 
 (122): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(4-methoxybenzyloxy)-[1,3,5]triazin-2-ylamine; 
 (123): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(4-dimethylaminophenylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (124): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propionic acid methyl ester; 
 (125): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propionamide; 
 (126): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propionic acid; 
 (127): N-{2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-yloxymethyl]-phenyl}-acetamide; 
 (128): N-{4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-yloxymethyl]-phenyl}-acetamide; 
 (129): N-{3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-yloxymethyl]-phenyl}-acetamide; 
 (130): (R)-2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanylmethyl]-4-oxo-pentanoic acid; 
 (131): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-2-methyl-propionic acid; 
 (132): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethanol; 
 (133): {2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-carbamic acid tert-butyl ester; 
 (134): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(3-dimethylaminophenylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (135): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-2-methyl-propionic acid methyl ester; 
 (136): (R)-2-acetylamino-3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propionic acid methyl ester; 
 (137): 4-(4-aminophenylsulfanyl)-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylamine; 
 (138): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(3-chloropropylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (139): 4-[4-(N,N-dimethylaminosulfonyl)amino-phenylsulfanyl]-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylamine; 
 (140): N-{4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanylmethyl]-phenyl}-acetamide; 
 (141): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(3-dimethylaminopropylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (142): 4-(4-aminosulfonyl)amino-phenylsulfanyl-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylamine; 
 (143): N-{2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanylmethyl]-phenyl}-acetamide; 
 (144): N-{3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanylmethyl]-phenyl}-acetamide; 
 (145): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(2,5-dimethoxyphenylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (149): N-{3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propyl}-acetamide; 
 (150): N-{4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-butyl}-acetamide; 
 (151): N-{2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-propionamide; 
 (152): N-{2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-butylamide; 
 (153): N-{2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-isobutylamide; 
 (154): cyclopropane carboxylic acid {2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-amide; 
 (155): cyclopentane carboxylic acid {2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-amide; 
 (156): tetrahydro-pyran-4-carboxylic acid {2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-amide; 
 (157): piperidine-4-carboxylic acid {2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-amide; 
 (158): 1-methyl-piperidine-4-carboxylic acid {2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-amide; 
 (159): N-{2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-3-hydroxypropionamide; 
 (160): N-{2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-3,4-dihydroxybutylamide; 
 (161): N-{2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-4-hydroxy-3-hydroxymethylbutylamide; 
 (162): N-{2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-N-methyl-acetamide; 
 (163): 1-{2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-pyrrolidin-2-one; 
 (164): N-{3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propyl}-propionamide; 
 (165): N-{3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propyl}-N-methyl-acetamide; 
 (166): N-{3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propyl}-3-hydroxypropionamide; 
 (167): N-{3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propyl}-3,4-dihydroxy-butylamide; 
 (168): N-{3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propyl}-4-hydroxy-3-hydroxymethyl-butylamide; 
 (169): 1-{3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propyl}-pyrrolidin-2-one; 
 (170): cyclopropane carboxylic acid {3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propyl}-amide; 
 (171): cyclopentane carboxylic acid {3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propyl}-amide; 
 (172): tetrahydro-pyran-4-carboxylic acid {3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propyl}-amide; 
 (173): piperidin-4-carboxylic acid {3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propyl}-amide; 
 (174): N-{2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-formamide; 
 (175): {2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-urea; 
 (176): 1-{2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-3-methylurea; 
 (177): {2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-carbamic acid methyl ester; 
 (178): N-{2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-methanesulfonamide; 
 (179): N-{3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-aminosulfonamide; 
 (180): N-{3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propyl}-formamide; 
 (181): {3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propyl}-urea; 
 (182): 1-{3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propyl}-3-methylurea; 
 (183): {3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propyl}-carbamic acid methyl ester; 
 (184): N-{3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propyl}-methanesulfonamide; 
 (185): N-{3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propyl}-aminosulfonamide; 
 (186): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(2-methyl-oxazol-4-ylmethylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (187): N-{2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-3-dimethylaminopriopionamide; 
 (188): N-{2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-isonicotinamide; 
 (189): 1H-imidazole-2-carboxylic acid {2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-amide; 
 (190): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(2-dimethylamino-ethylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (191): 4-(2-aminoethylsulfanyl)-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylamine; 
 (192): 4-(3-aminopropylsulfanyl)-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylamine; 
 (193): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(2-methylaminoethylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (194): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(3-methylaminopropylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (195): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(2-pyrrolidin-1-yl-ethylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (196): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(3-pyrrolidin-1-yl-propylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (197): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(2-morpholin-4-yl-ethylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (198): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(3-morpholin-4-yl-propylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (199): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(2-piperazin-1-yl-ethylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (200): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(3-piperazin-1-yl-propylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (201): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-[2-(pyridin-2-ylamino)-ethylsulfanyl]-[1,3,5]triazin-2-ylamine; 
 (202): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-[2-(oxazol-4-ylamino)-ethylsulfanyl]-[1,3,5]triazin-2-ylamine; 
 (203): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-2,2-difluoroacetamide; 
 (204): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-methyl-acetamide; 
 (205): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-methyl-propionamide; 
 (206): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-ethyl-acetamide; 
 (207): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-ethyl-propionamide; 
 (208): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N,N-dimethyl-acetamide; 
 (209): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N,N-dimethyl-propionamide; 
 (210): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-isopropyl-acetamide; 
 (211): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-isopropyl-propionamide; 
 (212): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-propyl-acetamide; 
 (213): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-propyl-propionamide; 
 (214): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-cyclopentyl-acetamide; 
 (215): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-cyclopentyl-propionamide; 
 (216): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-(tetrahydro-pyran-4-yl)-acetamide; 
 (217): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-(tetrahydro-pyran-4-yl)-propionamide; 
 (218): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-pyridin-4-yl-acetamide; 
 (219): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-pyridin-4-yl-propionamide; 
 (220): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-thiazol-2-yl-acetamide; 
 (221): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-thiazol-2-yl-propionamide; 
 (222): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-1-pyrrolidin-1-yl-ethanone; 
 (223): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-1-pyrrolidin-1-yl-propan-1-one; 
 (224): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-1-morpholin-4-yl-ethanone; 
 (225): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-1-morpholin-4-yl-propan-1-one; 
 (226): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-1-piperazin-1-yl-ethanone; 
 (227): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-1-(4-methyl-piperazin-1-yl)-propan-1-one; 
 (228): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-1-piperazin-1-yl-propan-1-one; 
 (229): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-thiazol-2-yl-acetamide; 
 (230): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-thiazol-2-yl-propionamide; 
 (231): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-isopropyl-propionamide; 
 (232): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-isopropyl-acetamide; 
 (233): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-(2-hydroxy-ethyl)-acetamide; 
 (234): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-(2-hydroxy-ethyl)-propionamide; 
 (235): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-(2,3-dihydroxypropyl)-acetamide; 
 (236): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-(2,3-dihydroxypropyl)-propionamide; 
 (237): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-(3-hydroxy-2-hydroxymethyl-propyl)-acetamide; 
 (238): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-(3-hydroxy-2-hydroxymethyl-propyl)-propionamide; 
 (239): 4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-butylamide; 
 (240): 4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-methyl-butylamide; 
 (241): 4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N,N-dimethyl-butylamide; 
 (242): 4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-ethyl-butylamide; 
 (243): 4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-1-pyrrolidin-1-yl-butan-1-one; 
 (244): 4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-1-morpholin-4-yl-butan-1-one; 
 (245): 4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-1-piperazin-1-yl-butan-1-one; 
 (246): 4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-(2-hydroxy-ethyl)-butylamide; 
 (247): 4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-(tetrahydro-pyran-4-yl)-butylamide; 
 (248): 4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-piperidin-4-yl-butylamide; 
 (249): 4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-pyridin-4-yl-butylamide; 
 (250): 4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-thiazol-2-yl-butylamide; 
 (251): 1-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propan-2-one; 
 (252): 4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-butan-2-one; 
 (253): N-{2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-acetyl}-acetamide; 
 (254): N-{3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propionyl}-acetamide; 
 (255): N-{4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-butyryl}-acetamide; 
 (256): N-{2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-acetyl}-methanesulfonamide; 
 (257): N-{3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propionyl}-methanesulfonamide; 
 (258): N-{4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-butyryl}-methanesulfonamide; 
 (259): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(oxazol-2-ylmethylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (260): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(2-oxazol-2-yl-ethylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (261): 1-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propan-2-one O-methyl-oxime; 
 (262): 4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-butan-2-one O-methyl-oxime; 
 (263): [4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-acetonitrile; 
 (264): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propionitrile; 
 (265): 4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-butyronitrile; 
 (266): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(2-methoxy-ethylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (267): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(3-methoxypropylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (268): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-[2-(2-methoxyethoxy)-ethylsulfanyl]-[1,3,5]triazin-2-ylamine; 
 (269): 4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-butan-1-ol; 
 (270): carbamic acid 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl ester; 
 (271): carbamic acid 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propyl ester; 
 (272): carbamic acid 4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-butyl ester; 
 (273): sulfamic acid 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl ester; 
 (274): sulfamic acid 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propyl ester; 
 (275): sulfamic acid 4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-butyl ester; 
 (276): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propane-1,2-diol; 
 (277): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanylmethyl]-propane-1,3-diol; 
 (278): thiocarbamic acid 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl ester; 
 (279): thiocarbamic acid 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propyl ester; 
 (280): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(2-methanesulfonyl-ethylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (281): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(3-methanesulfonyl-propylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (282): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propan-1-sulfonamide; 
 (283): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethanesulfonamide; 
 (284): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(3,3,3-trifluoro-propylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (285): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(4,4,4-trifluoro-butylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (286): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(3-fluoropropylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (287): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(4-fluorobutylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (288): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(oxazol-2-ylmethylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (289): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(thiazol-2-ylmethylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (290): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(2-thiazol-2-yl-ethylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (291): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(1H-imidazol-2-ylmethylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (292): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-[2-(1H-imidazol-2-yl)-ethylsulfanyl]-[1,3,5]triazin-2-ylamine; 
 (293): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(2-oxazol-3-yl-ethylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (294): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(pyridin-4-ylmethylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (295): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(2-pyridin-4-yl-ethylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (296): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(pyridin-2-ylmethylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (297): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(2-pyridin-2-yl-ethylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (298): 2-acetylamino-3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propionamide; 
 (299): 2-acetylamino-3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-methyl-propionamide; 
 (300): 2-acetylamino-3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-ethyl-propionamide; 
 (301): 2-acetylamino-3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N,N-dimethyl-propionamide; 
 (302): 2-amino-3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-methyl-propionamide; 
 (303): 2-amino-3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N,N-dimethyl-propionamide; 
 (304): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-(2-methoxy-ethyl)-acetamide; 
 (305): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-cyanomethyl-acetamide; 
 (306): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-(2-hydroxy-1-hydroxymethyl-ethyl)-acetamide; 
 (307): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-(2-diethylamino-ethyl)-acetamide; 
 (308): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-(1-methyl-piperidin-4-yl)-acetamide; 
 (309): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-(2-methoxy-ethyl)-propionamide; 
 (310): 1-{2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-imidazolin-2-one; 
 (311): 3-{2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-oxazolidin-2-one; 
 (312): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-1-pyrazin-2-yl-ethanone; 
 (313): 3-{2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-acetyl}-oxazolidin-2-one; 
 (314): 2-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-acetamide; 
 (315): 2-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-N-cyanomethyl-acetamide; 
 (316): 3-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-propionamide; 
 (317): 3-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-N-(2-hydroxy-ethyl)-propionamide; 
 (318): 3-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-N-methyl-propionamide; 
 (319): 3-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-N-(2-methoxy-ethyl)-propionamide; 
 (320): 3-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-N-((R)-2,3-dihydroxy-propyl)-propionamide; 
 (321): 3-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-2-methyl-propionamide; 
 (322): 3-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-2,N-dimethyl-propionamide; 
 (323): 3-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-N-(2-hydroxy-ethyl)-2-methyl-propionamide; 
 (324): 4-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-butylamide; 
 (325): carbamic acid 2-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-ethyl ester; 
 (326): 3-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-propan-1-ol; 
 (327): N-{2-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-ethyl}-acetamide; 
 (328): N-{3-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-propyl}-acetamide; 
 (329): N-{2-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-ethyl}-methanesulfonamide; 
 (330): 5-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanylmethyl]-oxazolidin-2-one; 
 (331): N-{2-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-ethyl}-2-hydroxy-acetamide; 
 (332): {2-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-ethyl}-urea; 
 (333): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-cyanomethyl-acetamide; 
 (334): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-(2-methoxy-ethyl)-propionamide; 
 (335): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-((R)-2,3-dihydroxy-propyl)-propionamide; 
 (336): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-2-methyl-propionamide; 
 (337): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-2,N-dimethyl-propionamide; 
 (338): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-(2-hydroxy-ethyl)-2-methyl-propionamide; 
 (339): 4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-butyramide; 
 (340): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propan-1-ol; 
 (341): 5-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanylmethyl]-oxazolidin-2-one; 
 (342): N-{2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-2-hydroxy-acetamide; and 
 (343): 4-[4-amino-6-(5-chloro-1H,3H-2-thia-phenalen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-butyramide. 
 
     
     
       13. A compound or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of:
 (82): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(3,4-dimethoxyphenoxy)-[1,3,5]triazin-2-ylamine; 
 (92): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-cyclohexylsulfanyl-[1,3,5]triazin-2-ylamine; 
 (111): [4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-acetic acid methyl ester; 
 (113): N-{2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-acetamide; 
 (119): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-acetamide; 
 (125): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propionamide; 
 (143): N-{2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanylmethyl]-phenyl}-acetamide; 
 (145): 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(2,5-dimethoxyphenylsulfanyl)-[1,3,5]triazin-2-ylamine; 
 (149): N-{3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propyl}-acetamide; 
 (175): {2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-urea; 
 (178): N-{2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-methanesulfonamide; 
 (205): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-methyl-propionamide; 
 (234): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-(2-hydroxy-ethyl)-propionamide; 
 (270): carbamic acid 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl ester; 
 (314): 2-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-acetamide; 
 (315): 2-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-N-cyanomethyl-acetamide; 
 (316): 3-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-propionamide; 
 (317): 3-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-N-(2-hydroxy-ethyl)-propionamide; 
 (318): 3-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-N-methyl-propionamide; 
 (319): 3-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-N-(2-methoxy-ethyl)-propionamide; 
 (320): 3-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-N-((R)-2,3-dihydroxy-propyl)-propionamide; 
 (321): 3-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-2-methyl-propionamide; 
 (322): 3-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-2,N-dimethyl-propionamide; 
 (323): 3-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-N-(2-hydroxy-ethyl)-2-methyl-propionamide; 
 (324): 4-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-butylamide; 
 (325): carbamic acid 2-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-ethyl ester; 
 (326): 3-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-propan-1-ol; 
 (327): N-{2-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-ethyl}-acetamide; 
 (328): N-{3-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-propyl}-acetamide; 
 (329): N-{2-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-ethyl}-methanesulfonamide; 
 (330): 5-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanylmethyl]-oxazolidin-2-one; 
 (331): N-{2-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-ethyl}-2-hydroxy-acetamide; 
 (332): {2-[2-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-pyrimidin-4-ylsulfanyl]-ethyl}-urea; 
 (333): 2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-cyanomethyl-acetamide; 
 (334): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-(2-methoxy-ethyl)-propionamide; 
 (335): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-((R)-2,3-dihydroxy-propyl)-propionamide; 
 (336): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-2-methyl-propionamide; 
 (337): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-2,N-dimethyl-propionamide; 
 (338): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-N-(2-hydroxy-ethyl)-2-methyl-propionamide; 
 (339): 4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-butyramide; 
 (340): 3-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-propan-1-ol; 
 (341): 5-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanylmethyl]-oxazolidin-2-one; 
 (342): N-{2-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-ethyl}-2-hydroxy-acetamide; and 
 (343): 4-[4-amino-6-(5-chloro-1H,3H-2-thia-phenalen-6-yl)-[1,3,5]triazin-2-ylsulfanyl]-butyramide. 
 
     
     
       14. A pharmaceutical composition comprising the compound or a pharmaceutically acceptable salt thereof according to  claim 1 , and a pharmaceutically acceptable carrier. 
     
     
       15. A compound represented by formula (8a) or a salt thereof: 
       
         
           
           
               
               
           
         
         wherein,
 X represents CH or N; 
 R 1  represents a hydrogen atom, halogen atom, cyano group, C 1-6  alkyl group, C 1-4  haloalkyl group, C 2-6  alkenyl group, C 2-6  alkynyl group, C 1-6  alkoxy group, or C 1-6  alkylthio group; and 
 Z′ represents a hydrogen atom, an optionally substituted C 1-10  alkyl group, an optionally substituted C 2-10  alkenyl group, an optionally substituted C 2-10  alkynyl group, an optionally substituted C 3-10  cycloalkyl group, an optionally substituted C 6-12  aryl group, an optionally substituted 5- to 12-membered heteroaryl group, or an optionally substituted 3- to 12-membered heterocycle. 
 
       
     
     
       16. The compound or salt thereof of  claim 15 , wherein Z′ is a hydrogen atom, or an optionally substituted C 1-10  alkyl group. 
     
     
       17. The compound or salt thereof of  claim 16 , wherein Z′ is a hydrogen atom, C 1-6  alkyl group, or benzyl group. 
     
     
       18. A method for treating breast cancer, comprising administering to a subject in need thereof an effective amount of the compound or a pharmaceutically acceptable salt thereof according to  claim 1 . 
     
     
       19. A method for treating colon cancer, comprising administering to a subject in need thereof an effective amount of the compound or a pharmaceutically acceptable salt thereof according to  claim 1 .