Use of an indazolemethoxyalkanoic acid for reducing triglyceride, cholesterol and glucose levels

Abstract

Use of a compound of formula (I) in which R, R′ and R″ have the meanings given in the description, optionally in the form of a salt thereof with a pharmaceutically acceptable organic or mineral base, to prepare a pharmaceutical composition for reducing the blood triglyceride, cholesterol and glucose levels.

1. A method for reducing blood triglyceride level, comprising administering, to a human in need thereof, an effective amount of a compound of formula (I): 
       
         
           
           
               
               
           
         
       
       wherein
 R and R′, which may be the same or different, are H or C 1-5  alkyl, and 
 R″ is H or C 1-4  alkyl, 
 
       or a pharmaceutically acceptable salt thereof. 
     
     
       2. A method according to  claim 1 , which comprises administering said compound of formula (I) or pharmaceutically acceptable salt thereof in an amount of 0.0001 to 100 mg/kg/day. 
     
     
       3. A method according to  claim 1 , which comprises administering said compound of formula (I) or pharmaceutically acceptable salt thereof in an amount of 0.05 to 50 mg/kg/day. 
     
     
       4. A method according to  claim 1 , which comprises administering said compound of formula (I) or pharmaceutically acceptable salt thereof in an amount of 0.1 to 10 mg/kg/day. 
     
     
       5. A method according to  claim 1 , wherein R″ is H and R and R′ are both CH 3 . 
     
     
       6. A method according to  claim 1 , which comprises administration of 
       
         
           
           
               
               
           
         
       
       wherein R and R′ are both CH 3 . 
     
     
       7. A method for reducing blood cholesterol level, comprising administering, to a human in need thereof, an effective amount of a compound of formula (I): 
       
         
           
           
               
               
           
         
       
       wherein
 R and R′, which may be the same or different, are H or C 1-5  alkyl, and 
 R″ is H or C 1-4  alkyl, 
 or a pharmaceutically acceptable salt thereof. 
 
     
     
       8. A method according to  claim 7 , wherein R″ is H and R and R′ are both CH 3 . 
     
     
       9. A method according to  claim 7 , which comprises administration of 
       
         
           
           
               
               
           
         
       
       wherein R and R′ are both CH 3 . 
     
     
       10. A method according to  claim 7 , which comprises administering said compound of formula (I) or pharmaceutically acceptable salt thereof in an amount of 0.0001 to 100 mg/kg/day. 
     
     
       11. A method according to  claim 7 , which comprises administering said compound of formula (I) or pharmaceutically acceptable salt thereof in an amount of 0.05 to 50 mg/kg/day. 
     
     
       12. A method according to  claim 7 , which comprises administering said compound of formula (I) or pharmaceutically acceptable salt thereof in an amount of 0.1 to 10 mg/kg/day.