Diabetic nephropathy therapies

Abstract

The present invention relates to methods and compounds for treating specific early stage aspects and late stage aspects of diabetic nephropathy. Methods and compounds for treating various physiological features associated with early stage and with late stage diabetic nephropathy are also provided.

1. A method for reducing albuminuria in a subject having or at risk for having diabetes or diabetic nephropathy, the method comprising administering to the subject a therapeutically effective amount of an antibody that inhibits connective tissue growth factor, wherein the antibody is identical to the antibody produced by the cell line identified by ATCC Accession No. PTA-6006. 
     
     
       2. The method of  claim 1 , wherein the albuminuria is microalbuminuria. 
     
     
       3. The method of  claim 1 , wherein the albuminuria is macroalbuminuria. 
     
     
       4. A method for reducing urinary albumin excretion in a subject having or at risk for having diabetes or diabetic nephropathy, the method comprising administering to the subject a therapeutically effective amount of an antibody that inhibits connective tissue growth factor, wherein the antibody is identical to the antibody produced by the cell line identified by ATCC Accession No. PTA-6006.