Compounds

Abstract

The present invention provides named compounds of formula (I) and pharmaceutical compositions containing them and their use in therapy.

1. A compound having the following formula: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
       2. A pharmaceutical composition comprising the compound of  claim 1  or a pharmaceutically acceptable salt thereof in association with a pharmaceutically acceptable adjuvant, diluent or carrier. 
     
     
       3. A pharmaceutical combination comprising the compound of  claim 1  or a pharmaceutically acceptable salt thereof, one or more agents independently selected from:
 a selective β 2  adrenoreceptor agonist; 
 a phosphodiesterase inhibitor; 
 a protease inhibitor; 
 an anticholinergic agent; 
 a modulator of chemokine receptor function; and 
 an inhibitor of kinase function; 
 and optionally one or more pharmaceutically acceptable excipients. 
 
     
     
       4. A kit comprising a preparation of a first active ingredient which is the compound of  claim 1  or a pharmaceutically acceptable salt thereof, and a preparation of a second active ingredient which is
 a selective β 2  adrenoreceptor agonist; 
 a phosphodiesterase inhibitor; 
 a protease inhibitor; 
 an anticholinergic agent; 
 a modulator of chemokine receptor function; or 
 an inhibitor of kinase function; 
 and instructions for the simultaneous, sequential or separate administration of the preparations to a patient in need thereof. 
 
     
     
       5. A method of treating, or reducing the risk of, asthma comprising administering to a patient in need thereof a therapeutically effective amount of the compound of  claim 1  or a pharmaceutically acceptable salt thereof. 
     
     
       6. A method of treating, or reducing the risk of, chronic obstructive pulmonary disease comprising administering to a patient in need thereof a therapeutically effective amount of the compound of  claim 1  or a pharmaceutically acceptable salt thereof. 
     
     
       7. A process for preparing the pharmaceutical composition of  claim 2 , comprising mixing the compound of  claim 1  or a pharmaceutically acceptable salt thereof with a pharmaceutically acceptable adjuvant, diiluent, or carrier.