Inhibiting Staphylococcus epidermidis infections

Abstract

The invention relates to Staphylococcus epidermidis peptides, antibodies and nucleic acids that can inhibit Staphylococcus epidermidis infection of a mammalian subject and colonization of a medical device in the mammal.

1. An isolated  Staphylococcus epidermidis  SdrF peptide consisting of any of SEQ ID NOs: 3-9, or 31. 
     
     
       2. A composition comprising a pharmaceutically acceptable carrier and the peptide of  claim 1 . 
     
     
       3. A method of treating or inhibiting  Staphylococcus epidermidis  infection in a mammal comprising administering to the mammal a composition comprising an isolated  Staphylococcus epidermidis  SdrF peptide consisting of any of SEQ ID NO:3-9, 31, or a combination thereof to thereby treat or inhibit  Staphylococcus epidermidis  infection in a mammal. 
     
     
       4. The method of  claim 3 , wherein the method inhibits  Staphylococcus epidermidis  colonization of a medical device in the mammal. 
     
     
       5. A composition comprising an isolated  Staphylococcus epidermidis  SdrF peptide consisting of any of SEQ ID NOS:3-9, 31, or a combination thereof.