US8444988B2ExpiredUtilityA1

Cancer treatment method

68
Assignee: LACKEY KAREN ELIZABETHPriority: Jan 16, 2001Filed: Nov 11, 2011Granted: May 21, 2013
Est. expiryJan 16, 2021(expired)· nominal 20-yr term from priority
Inventors:Karen Elizabeth LackeyRobert J. MullinNeil SpectorEdgar Raymond Wood, IiiWenle Xia
H10P 14/6922A61K 31/517A61K 31/555A61K 31/519A61K 31/475A61K 31/337A61K 45/06A61K 31/4196A61P 43/00A61P 35/00C23C 16/401
68
PatentIndex Score
2
Cited by
44
References
4
Claims

Abstract

A method of treating cancer is described including administration of a 4-quinazolineamine and at least one other anti-neoplastic agent as well as a pharmaceutical combination including the 4-quinazolineamines.

Claims

exact text as granted — not AI-modified
We claim: 
     
       1. A method of treating breast cancer in a mammal, comprising administering to said mammal a therapeutically effective amount of:
 (a) the compound of formula II: 
 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof; and
 (b) trastuzumab. 
 
     
     
       2. The method of  claim 1 , wherein the mammal is human. 
     
     
       3. The method of  claim 1 , wherein the pharmaceutically acceptable salt is ditosylate. 
     
     
       4. A method of treating breast cancer in a mammal, comprising administering to said mammal a therapeutically effective amount of:
 (a) 
 
       
         
           
           
               
               
           
         
       
       ditosylate monohydrate; and
 (b) trastuzumab.

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