Multi-drug ligand conjugates

Abstract

Described herein are compounds, pharmaceutical compositions and methods for treating pathogenic cell populations in a patient. The compounds described herein include conjugates of a plurality of cytotoxic drugs and vitamin receptor binding ligands. The plurality of drugs may be the same or different. Similarly, the vitamin receptor binding ligands may be the same or different. The conjugates also include a linker that is formed from one or more spacer linkers, heteroatom linkers, and releasable linkers.

What is claimed is: 
     
       1. A compound of the formula 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof, wherein q is an integer from 0 to 8; or 
       
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof, wherein AA forms an amino acid; and n is an integer from 0 to 8. 
       
     
     
       2. The compound of  claim 1  wherein q is 1 to 8. 
     
     
       3. The compound of  claim 1  wherein n is 1 to 8. 
     
     
       4. A compound of the formula 
       
         
           
           
               
               
           
         
         or 
       
       
         
           
           
               
               
           
         
         or 
       
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
       5. The compound of  claim 4  the formula 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
       6. The compound of  claim 4  the formula 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
       7. The compound of  claim 4  the formula 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
       8. A pharmaceutical composition comprising a drug delivery conjugate of  claim 4 , and a pharmaceutically acceptable carrier, diluent, or excipient therefor. 
     
     
       9. A pharmaceutical composition comprising the compound of  claim 1 , and a pharmaceutically acceptable carrier, diluent, or excipient therefor.