Cyanoacrylate initiator system

Abstract

The present invention is directed to curable compositions that comprise a non-porous substrate, one or more cyanoacrylate polymerization initiators and a prepolymer composition comprising at least one liquid cyanoacrylate monomer or mixture of such monomers (solid or liquid) and/or cyanoacrylate oligomers. The non-porous substrate is a collection of individual particulates that are not bound, bonded or fixed to one another. At least one initiator is deposited on the surface of the individual particulates to form a plurality of initiator carriers. The prepolymer composition receives the plurality of initiator carriers to begin a controlled and consistent polymerization or curing of the liquid cyanoacrylate monomer in order to produce a biocompatible adhesive composition for use on living tissue. The present invention also provides for methods of making and using and devices for such a curable compositions, particularly in treating living tissue by applying to living tissue a biocompatible adhesive composition.

I claim: 
     
       1. A curable composition comprising
 a. a non-porous substrate, 
 b. one or more cyanoacrylate polymerization initiators and 
 c. a prepolymer composition comprising at least one liquid cyanoacrylate monomer or mixture of cyanoacrylate monomers and/or cyanoacrylate oligomers, 
 wherein the non-porous substrate is composed of a plurality of individual particulates that are not bound, bonded or fixed to one another and are solid, organic polymeric material or solid, inorganic-organic hybrid material, 
 wherein the plurality of individual particulates, prior to being coated with initiator, have a specific surface area from 30 to 600 cm 2 /g, and 
 wherein the one or more cyanoacrylate initiators are deposited on the surface of the plurality of individual particulates to form a plurality of initiator carriers. 
 
     
     
       2. The curable composition according to  claim 1  wherein the plurality of individual particulates, prior to being coated with initiator, have an average particle size from about 0.05 mm to about 5 mm. 
     
     
       3. The curable composition according to  claim 1  wherein the plurality of individual particulates, prior to being coated with initiator, have an average particle size of from about 0.10 mm to about 2.5 mm. 
     
     
       4. The curable composition according to  claim 1  wherein the plurality of individual particulates, prior to being coated with initiator, have an average particle size of from about 0.15 mm to about 2.5 mm. 
     
     
       5. The curable composition according to  claim 1  wherein the plurality of individual particulates, prior to being coated with initiator, have an average mesh size from about 3 to about 270 US mesh. 
     
     
       6. The curable composition according to  claim 1  wherein the plurality of individual particulates, prior to being coated with initiator, have an average mesh size ranging from about 7 to about 140 US mesh. 
     
     
       7. The curable composition according to  claim 1  wherein the plurality of individual particulates, prior to being coated with initiator, have an average mesh size ranging from about 7 to about 100 US mesh.