US8476450B2ExpiredUtilityA1

Luminogenic and fluorogenic compounds and methods to detect molecules or conditions

87
Individually held — no corporate assignee on recordPriority: May 31, 2005Filed: Jul 3, 2008Granted: Jul 2, 2013
Est. expiryMay 31, 2025(expired)· nominal 20-yr term from priority
Inventors:James J. CaliWilliam DailyErika HawkinsDieter KlaubertJianquan LiuPoncho MeisenheimerMichael ScurriaJohn ShultzJames UnchMichael P. ValleyKeith V. WoodWenhui Zhou
C09B 19/00C07D 311/16C09B 57/00G01N 2500/00C07D 417/14C07D 277/66C07D 277/68C12Q 1/66C07F 9/65583C09B 11/24C07D 417/04C09B 57/02C07D 493/10
87
PatentIndex Score
6
Cited by
276
References
2
Claims

Abstract

A method to detect the presence or amount of at least one molecule in a sample which employs a derivative of luciferin or a derivative of a fluorophore is provided. Compounds and compositions for carrying out the methods of the invention are also provided.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
       1. A compound according to formula VI: 
       
         
           
           
               
               
           
         
         wherein R 1  is —NR N1 R N2 ; wherein R N1  is H, C 3-8 alkyl which may be substituted with hydroxyl, halo, or amino, or —CH 2 -A 1  or —CH 2 -A 2 ; 
         R N2  is C 3-8 alkyl which may be substituted with hydroxyl, halo, or amino or —CH 2 -A 1  or —CH 2 -A 2 ; or 
         A 1  is C 6-10 aryl or C 6-10 heteroaryl, which may be substituted with hydroxyl, halo, or amino; 
         A 2  is C 6  aryl or C 6  heteroaryl, which may be substituted with hydroxyl, halo, or amino; and only one of R N1  or R N2  may be —CH 2 -A 1 ; 
         R 6  is COR 11  wherein R 11  is OH; 
         R 7  is H. 
       
     
     
       2. A compound selected from the group consisting of

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