US8504169B2ActiveUtilityA1
Drug retaining surface features in an implantable medical device
Est. expiryMay 13, 2031(~4.8 yrs left)· nominal 20-yr term from priority
A61M 37/00A61N 1/0541A61F 11/00
55
PatentIndex Score
1
Cited by
14
References
37
Claims
Abstract
An implantable component of a medical device, comprising a polymeric surface. The component includes one or more macro-surface features at the polymeric surface having a configuration that, following application of a liquid drug to the surface retains a quantity of the liquid drug adjacent the surface.
Claims
exact text as granted — not AI-modifiedWhat is claimed is:
1. An elongate implantable stimulating assembly, comprising:
a carrier member;
a plurality of electrode contacts disposed in a first portion of the carrier member; and
one or more macro-surface features, including at least one indentation or at least one protrusion, disposed in a second portion of the carrier member,
the macro-surface features having a configuration that enables the carrier member, following application of a liquid drug having cohesive forces to the carrier member, to retain a quantity of the drug.
2. The carrier member of claim 1 , wherein the indentations comprise a roughened, undulating region of the carrier member having a having a plurality of ridges and valleys.
3. The carrier member of claim 1 , wherein the indentations are apertures in the carrier member.
4. The carrier member of claim 3 , wherein the apertures are lateral apertures extending from the lateral surface towards the center of the carrier member.
5. The carrier member of claim 3 , wherein the apertures are transverse apertures extending transversely through a portion of the carrier member.
6. The carrier member of claim 1 , wherein the macro-surface features are longitudinal channels in the carrier member.
7. The carrier member of claim 1 , wherein the macro-surface features are transverse channels in the carrier member.
8. The carrier member of claim 1 , wherein the protrusions are substantially planar protrusions having a curved outer surface.
9. The carrier member of claim 1 , wherein the protrusions are bumps extending from the carrier member surface.
10. The carrier member of claim 1 , wherein the protrusions are fibrous protrusions.
11. The carrier member of claim 1 , wherein the carrier member is a first material, and wherein the protrusions are a second material.
12. The carrier member of claim 11 , wherein the protrusions are a bio-resorbable material.
13. The carrier member of claim 1 , wherein the one or more macro-surface features comprise an absorbent layer attached to the carrier member surface.
14. The carrier member of claim 1 , further comprising:
a first arrangement of macro-surface features at a first region of the carrier member; and
a second arrangement of macro-surface features at a second region of the carrier member.
15. The carrier member of claim 1 , further comprising:
a drug release impeding coating.
16. A method of delivering drugs to a recipient using an implantable component of a medical device, wherein the component comprises a plurality of electrode contacts disposed in a first portion of the implantable component and a plurality of macro-surface features, including at least one indentation or at least one protrusion, disposed in a second portion of the carrier member, the macro-surface features having a configuration that enables the implantable component to retain a quantity of a liquid drug, the method comprising:
applying one or more liquid drugs to the component; and
implanting the implantable component into the recipient.
17. The method of claim 16 , wherein applying the one or more liquid drugs to the carrier member comprises:
dipping a first length of the carrier member into a first liquid drug; and
dipping a second length of the carrier member into a second liquid drug.
18. The method of claim 17 , wherein the first length of the carrier is different than the second length of the carrier member.
19. The method of claim 17 , wherein the first length of the carrier is the same as the second length of the carrier member.
20. The method of claim 16 , wherein applying the one or more liquid drugs to the carrier member comprises:
dipping a first length of the carrier member into a first liquid drug; and
dipping a first portion of the first of the carrier member into a removal solution so as to remove the first drug from the first portion;
dipping the first portion of the carrier member into a second liquid drug.
21. The method of claim 16 , further comprising:
coating the carrier member with a drug release impeding material.
22. An implantable component of a medical device, comprising:
a polymeric surface;
a plurality of electrode contacts disposed in a first portion of the polymeric surface; and
one or more macro-surface features, including at least one indentation or at least one protrusion, disposed in a second portion of the polymeric surface, the marco-surface features having a configuration that enables the carrier member, following application of a liquid drug having cohesive forces to the surface, to retain a quantity of the liquid drug adjacent the surface.
23. The implantable component of claim 22 , wherein the indentations comprise a roughened, undulating region of the component having a having a plurality of ridges and valleys.
24. The implantable component of claim 22 , wherein indentations are apertures in the component.
25. The implantable component of claim 24 , wherein the component is a stimulator/receiver unit.
26. The implantable component of claim 22 , wherein the indentations are channels in the surface of the component.
27. The implantable component of claim 22 , wherein the protrusions are fibrous protrusions.
28. The implantable component of claim 22 , wherein the polymeric surface is a first material, and wherein the protrusions are a second material.
29. The implantable component of claim 28 , wherein the protrusions are a bio-resorbable material.
30. The implantable component of claim 22 , wherein the one or more macro-surface features comprise an absorbent layer attached to the polymeric surface.
31. The implantable component of claim 22 , wherein the one or more surface features comprise:
a first arrangement of macro-surface features at a first region of the component surface; and
a second arrangement of macro-surface features at a second region of the component surface.
32. An implantable component of a medical device, comprising:
a polymeric surface;
a plurality of electrode contacts disposed in a first portion of the polymeric surface; and
one or more protrusions at the polymeric surface, disposed in a second portion of the carrier member, the macro-surface features having a configuration that enables the carrier member, following application of a liquid drug having cohesive forces to the surface, to retain a quantity of the liquid drug adjacent the surface.
33. The implantable component of claim 32 , wherein the protrusions are fibrous protrusions.
34. The implantable component of claim 32 , wherein the polymeric surface is a first material, and wherein the protrusions are a second material.
35. The implantable component of claim 34 , wherein the protrusions are a bio-resorbable material.
36. The implantable component of claim 34 , wherein the protrusions are substantially planar protrusions having a curved outer surface.
37. The implantable component of claim 34 , wherein the protrusions are bumps extending from the surface of the component.Cited by (0)
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