Phospholipid analogs as diapeutic* agents and methods thereof

Abstract

The present invention provides methods and uses of phospholipid ether analogs as diagnostic and therapeutic agents for numerous cancers.

What is claimed is: 
     
       1. A method for the treatment of a cancer in a subject comprising administering to the subject an effective amount of a molecule comprising a phospholipid ether analog, wherein the phospholipid ether analog is 18-(p-iodophenyl)octadecyl phosphocholine wherein the iodo moiety of the 18-(p-iodophenyl)octadecyl phosphocholine is  125 I or  131 I, and wherein said cancer is selected from the group consisting of lung cancer, squamous cell carcinoma, melanoma, colorectal cancer, ovarian cancer, prostate cancer, glioma, breast cancer, carcinosarcoma, and pancreatic cancer. 
     
     
       2. The method of  claim 1 , wherein the radioactive isotope of iodine is  131 I. 
     
     
       3. The method of  claim 1 , further comprising administering 5-20 μCi/200 g of body weight of the phospholipid ether analog to the subject. 
     
     
       4. The method of  claim 1 , further comprising administering 15-20 μCi/200 g of body weight of the phospholipid ether analog to the subject. 
     
     
       5. The method of  claim 1 , wherein the radioactive isotope of iodine is  125 I.