Compositions comprising dietary fat complexer and methods for their use

Abstract

This invention relates to fat containing consumable food products comprising α-cyclodextrin. The food products have reduced levels of bioavailable fat but have substantially the same fat, cholesterol and caloric content as a like food without α-cyclodextrin. The invention also relates to methods for reducing the bioavailability of fats in fat containing food products without reducing caloric intake as determined by bomb calorimetry and to methods for increasing high density lipoproteins in a subject and reducing or controlling weight by administering the food products of this invention.

We claim: 
     
       1. A consumable farinaceous food product comprising α-cyclodextrin and fat, wherein said food product has a ratio of α-cyclodextrin to fat of 1:20 w/w to about 1:3 w/w of said food product comprising less than about 9% w/w total cyclodextrin. 
     
     
       2. The consumable food product of  claim 1 , comprising at least about 7% to about 80% fat by caloric content. 
     
     
       3. The consumable food product of  claim 1  comprising less than about 6% w/w total cyclodextrin. 
     
     
       4. The consumable food product of  claim 1  wherein the food product is cooked. 
     
     
       5. The consumable farinaceous food product of  claim 1  comprising less than about 3% w/w total cyclodextrin. 
     
     
       6. A consumable non-farinaceous food product comprising complexes of α-cyclodextrin and fat, wherein said food product has a ratio of α-cyclodextrin to fat of 1:20 w/w to  about 1:3 w/w of said food product. 
     
     
       7. The consumable food product of  claim 6  wherein said non-farinaceous food product is a dairy, meat or vegetable food product. 
     
     
       8. The consumable food product of  claim 7  comprising less than about 9% w/w total cyclodextrin. 
     
     
       9. The consumable food product of  claim 6  comprising 5% to 50% fat w/w. 
     
     
       10. The consumable non-farinaceous food product of  claim 6 , wherein said food product has a ratio of α-cyclodextrin to fat of about 1:13 w/w to about 1:5 w/w of said food product. 
     
     
       11. A method for increasing the level of high density lipoprotein (HDL) cholesterol or reducing leptin levels, insulin levels or insulin resistance in a subject in need thereof comprising administering α-cyclodextrin to a subject in need thereof in an amount sufficient to increase HDL levels or reducing leptin levels, insulin levels or insulin resistance. 
     
     
       12. The method of  claim 11  wherein about 165 mg to 11 g of α-cyclodextrin is administered to said subject with a fat containing meal. 
     
     
       13. The method of  claim 11 , wherein said subject consumes about 100 g fat per day. 
     
     
       14. The method of  claim 11 , wherein α-cyclodextrin is in an amount such that it is in a ratio of 1:20 to about 1:3 of fat ingested daily by the subject. 
     
     
       15. The method of  claim 14  wherein about 500 mg to 33 g of α-cyclodextrin is administered to the subject in need thereof daily to increase the level of high density lipoprotein (HDL). 
     
     
       16. The method of  claim 11 , wherein total cholesterol levels are not increased in said subject. 
     
     
       17. The method of  claim 11 , wherein the α-cyclodextrin is administered in a form selected from the group consisting of a tablet, powder, capsule, liquid and a confection. 
     
     
       18. The method of  claim 11 , wherein the α-cyclodextrin is administered to the subject in the form of the consumable food product comprising α-cyclodextrin and fat wherein the ratio of α-cyclodextrin to fat is about 1:20 w/w to 1:3 w/w of said food product. 
     
     
       19. A method of reducing triglyceride levels in a subject comprising administering to a subject in need thereof an amount of α-cyclodextrin wherein the amount of α-cyclodextrin administered to said subject and fat ingested daily by said subject is in a ratio of about 1:20 to about 1:3 w/w. 
     
     
       20. The method of  claim 19 , wherein the α-cyclodextrin is administered in the form of a tablet, powder, capsule, liquid or confection. 
     
     
       21. The method of  claim 19 , wherein the α-cyclodextrin is administered to the subject in the form of the consumable food product comprising α-cyclodextrin and fat wherein the ratio of α-cyclodextrin to fat is about 1:20 w/w to 1:3 w/w of said food product. 
     
     
       22. The method of  claim 19  wherein about 500 mg to 33 g of α-cyclodextrin is administered to the subject in need thereof daily.