Monoclonal antibodies against dendritic cell receptor

Abstract

The invention provides isolated human DEC-205, its extracellular domain and functionally equivalent fragments thereof. Also provided are polynucleotides encoding same and vectors which include such polynucleotides. Further provided are methods of recombinantly producing human DEC-205, an extracellular domain thereof or a functionally equivalent fragment, and ligands that bind to human DEC-205 or a fragment thereof. Also provided are constructs for use in prophylaxis or therapy comprising such a ligand, human DEC-205 or an extracellular domain thereof coupled to a toxin or to an antigen capable of inducing a protective immune response in a patient.

The invention claimed is: 
     
       1. An isolated monoclonal antibody that specifically binds to human DEC-205 which has the amino acid sequence set forth in SEQ ID NO: 1, wherein the monoclonal antibody specifically binds the amino acid sequence of SEQ ID NO: 33 (ATTQDEVHTKC). 
     
     
       2. An antigen binding fragment of the antibody as claimed in  claim 1 .